推荐产品
检测方案
98%
形式
liquid
折射率
n20/D 1.509 (lit.)
密度
1.724 g/mL at 25 °C (lit.)
SMILES字符串
Fc1cccc(Br)c1F
InChI
1S/C6H3BrF2/c7-4-2-1-3-5(8)6(4)9/h1-3H
InChI key
RKWWASUTWAFKHA-UHFFFAOYSA-N
一般描述
Microbial oxidation of 1-bromo-2,3-difluorobenzene by Pseudomonas putida strain 39/D and Escherichia coli recombinant microorganism (strain JM 109(pDTG601)) has been reported.
应用
1-Bromo-2,3-difluorobenzene may be used in the synthesis of potent, orally active Calcitonin gene-related peptide (CGRP) receptor antagonist (BMS-846372). It may be used in the preparation of 2,3-difluorophenyl(dimethyl)phosphane.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
141.8 °F
闪点(°C)
61 °C
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
监管及禁止进口产品
New metabolites from the microbial oxidation of fluorinated aromatic compounds.
Hudlicky T, et al.
Journal of Fluorine Chemistry, 89(1), 23-30 (1998)
Reaction of chloropentafluorobenzene and 2, 3-and 2, 6-difluorobromobenzenes with lithium dimethylphosphide.
Goryunov LI, et al.
Russ. J. Org. Chem., 45(12), 1859-1861 (2009)
Guanglin Luo et al.
ACS medicinal chemistry letters, 3(4), 337-341 (2012-04-12)
Calcitonin gene-related peptide (CGRP) receptor antagonists have been clinically shown to be effective in the treatment of migraine, but identification of potent and orally bioavailable compounds has been challenging. Herein, we describe the conceptualization, synthesis, and preclinical characterization of a
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