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线性分子式:
BrCH2CH2CHBrCOCl
化学文摘社编号:
分子量:
264.34
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4955401
产品名称
2,4-二溴丁酰氯, technical, ~90% (GC)
InChI
1S/C4H5Br2ClO/c5-2-1-3(6)4(7)8/h3H,1-2H2
SMILES string
ClC(=O)C(Br)CCBr
InChI key
WYZLYWUZERABRL-UHFFFAOYSA-N
grade
technical
assay
~90% (GC)
refractive index
n20/D 1.535
density
2.00 g/mL at 20 °C
functional group
acyl chloride
bromo
storage temp.
2-8°C
Quality Level
Application
2,4-Dibromobutyryl chloride was used in the preparation of:
- methyl 2,4-dibromobutanoate
- series of 3-(3, 5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones, anti-inflammatory/analgesic agents
- α-bromolactam
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
supp_hazards
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates.
Ma S, et al.
Tetrahedron Letters, 48(2), 269-271 (2007)
H Ikuta et al.
Journal of medicinal chemistry, 30(11), 1995-1998 (1987-11-01)
A series of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones was synthesized and evaluated as candidate antiinflammatory/analgesic agents as well as dual inhibitors of prostaglandin and leukotriene synthesis. Some compounds that showed dual inhibitory activity were found to possess equipotent antiinflammatory activities to indomethacin, with reduced
Bhooma Raghavan et al.
The Journal of organic chemistry, 71(5), 2151-2154 (2006-02-25)
A concise, stereoselective synthesis of alpha-substituted gamma-lactams is reported. gamma-Lactam scaffolds 2 and 3, possessing an Evans' chiral auxiliary and two types of N substituents, were successfully alkylated with different electrophiles to give alpha-substituted gamma-lactams with reasonable diastereoselectivities. The use
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