推荐产品
检测方案
99%
形式
liquid
折射率
n20/D 1.533 (lit.)
bp
70-71 °C/7 mmHg (lit.)
密度
1.108 g/mL at 25 °C (lit.)
SMILES字符串
Cc1ccc(N)c(F)c1
InChI
1S/C7H8FN/c1-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3
InChI key
ZQEXBVHABAJPHJ-UHFFFAOYSA-N
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一般描述
Rat liver microsomal metabolism of 2-fluoro-4-methylaniline was studied by HPLC.
应用
2-Fluoro-4-methylaniline was used in the preparation of 6-chloro-5-fluoroindole via Leimgruber-Batcho reaction. It was also used in the preparation of an (S)-amino alcohol, 2-amino-3-(2-fluoro-4-methylphenyl)-propan-1-ol.
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
174.2 °F
闪点(°C)
79 °C
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
S Boeren et al.
Xenobiotica; the fate of foreign compounds in biological systems, 22(12), 1403-1423 (1992-12-01)
1. Rat liver microsomal metabolism of 2-fluoro-, 2-chloro- and 2-bromo-4-methylaniline was investigated using h.p.l.c. Metabolites identified include products from side-chain C-hydroxylation (benzyl alcohols and benzaldehydes) and N-hydroxylation (hydroxylamines and nitroso derivatives). Aromatic ring hydroxylation was not a major reaction pathway.
Sharon T Marino et al.
Molecules (Basel, Switzerland), 9(6), 405-426 (2007-11-17)
In the past decade there has been a significant growth in the sales of pharmaceutical drugs worldwide, but more importantly there has been a dramatic growth in the sales of single enantiomer drugs. The pharmaceutical industry has a rising demand
J M Bentley et al.
Bioorganic & medicinal chemistry letters, 14(9), 2367-2370 (2004-04-15)
A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for all of the compounds
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