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332607

Sigma-Aldrich

（2-羟丙基）-β-环糊精

average Mw ~1,460

别名:

(2-羟丙基)-β-环糊精, HP-β-CD

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About This Item

CAS号:
128446-35-5
EC 号:
420-920-1
UNSPSC代码:
12352201
PubChem化学物质编号:
24859911
NACRES:
NA.22

表单

powder

质量水平

200

旋光性

[α]25/D +135°, c = 1 in H2O (typical)

分子量

average Mw ~1,460

标记范围

0.8 molar substitution

mp

267 °C (dec.)

溶解性

water: 180 g/L

SMILES字符串

CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

InChI

1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1

InChI key

ODLHGICHYURWBS-RYJYQAAZSA-N

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一般描述

(2-羟丙基)-β-环糊精是一种羟烷基衍生物，经证可作为一种制剂载体，增强药物在水溶液中的溶解度，从而将药物成功递送至生物系统。通常用作α-、β-和γ-环糊精的替代物。

应用

(2-羟丙基)-β-环糊精可用于：
  • 作为薄层色谱法（TLC）测定药物制剂中分析物的分析标准品。
  • 在使用反相高效液相色谱(RP-HPLC)定量之前，研究宿主-客体的有机低分子量化合物相互作用。
  • 作为HPLC法有效分离β-咔啉的流动相添加剂。
  • 环糊精修饰的胶束电动色谱(CD-modified MEKC)测定盐酸舍曲林及与合成相关产物。

亲脂性药物的溶解度随着水溶液中的羟丙基-β-环糊精(HP-β-CD)浓度线性增加，这是因为HP-β-CD与药物形成了复合物。这种客体-宿主型复合物在药物与HP-β-CD的非极性空穴间形成，导致溶解度增强。HP-β-CD可用于制备与罗哌卡因(RVC)形成的包合物，以增加RVC溶解度，确保有效的药物递送。
亲脂性药物的溶解度随着水溶液中的羟丙基-β-环糊精（HBC）浓度线性增加，这是因为HBC与药物形成了复合物。这种客体-宿主型复合物在药物与HBC的非极性空穴间形成，导致溶解度增强。 可以将溶液冻干以产生易溶的粉末。 对家兔和小鼠无毒性。

储存分类代码

13 - Non Combustible Solids

WGK

WGK 1

闪点(°F)

>752.0 °F

闪点(°C)

> 400 °C

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM4393
BCCL3259
BCCL9564
WXBF1726V
WXBD9912V

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