推荐产品
产品名称
L-丙氨酸甲酯 盐酸盐, 99%
质量水平
方案
99%
旋光性
[α]25/D +7.0°, c = 1.6 in methanol
反应适用性
reaction type: solution phase peptide synthesis
mp
109-111 °C (lit.)
应用
peptide synthesis
SMILES字符串
Cl.COC(=O)[C@H](C)N
InChI
1S/C4H9NO2.ClH/c1-3(5)4(6)7-2;/h3H,5H2,1-2H3;1H/t3-;/m0./s1
InChI key
IYUKFAFDFHZKPI-DFWYDOINSA-N
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一般描述
L-丙氨酸甲酯盐酸盐，又称为L-Ala-OMe·HCl，是一种多功能试剂，常用于液相多肽合成法。常用于合成二肽。
应用
L-丙氨酸甲酯盐酸盐可作为起始材料用于液相多肽合成法合成丙氨酸异恶唑烷(alanine isoxazolidide)。也用于合成N-Fmoc-l-丙氨酰-l-丙氨酸甲酯和α-氨基酸基树枝化基元(sector block dendrons)。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
N-methylation of peptides on selected positions during the elongation of the peptide chain in solution phase
ML Di Gioia
The Journal of Organic Chemistry, 70, 3892-3897 (2005)
Synthesis and gelation properties of a new class of $\alpha$-amino acid-based sector block dendrons
HF Chow
Tetrahedron, 61, 11279-11290 (2005)
The dimethylsulfoxonium methylide as unique reagent for the simultaneous deprotection of amino and carboxyl function of N-Fmoc-?-amino acid and N-Fmoc-peptide esters
M Spinella
Tetrahedron, 69, 2010-2016 (2013)
Hala Bakr El-Nassan et al.
Pharmaceutical research, 35(8), 149-149 (2018-05-31)
To assess the gelation power of N-palmitoyl L-alanine derivatives in injectable oils and to use the best chosen organogel as parenteral implant of granisetron for the treatment of emesis. Twelve N-palmitoyl L-alanine derived organogels were developed and evaluated in terms
Jingwen Luo et al.
Drug development and industrial pharmacy, 45(1), 96-104 (2018-09-11)
This article aims to design low molecular weight chitosan (LMWC)-based conjugates of Rhein (RH) by means of an amino acid linker (Alanine) for improved solubility and enhanced bioavailability. Rhein is a potential candidate for the therapy of kidney disease. However
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