推荐产品
蒸汽压
10 mmHg ( 20 °C)
质量水平
检测方案
98%
形式
liquid
折射率
n20/D 1.488 (lit.)
bp
74-76 °C/40 mmHg (lit.)
mp
1-3 °C (lit.)
密度
1.183 g/mL at 25 °C (lit.)
储存温度
2-8°C
SMILES字符串
ClC\C=C\CCl
InChI
1S/C4H6Cl2/c5-3-1-2-4-6/h1-2H,3-4H2/b2-1+
InChI key
FQDIANVAWVHZIR-OWOJBTEDSA-N
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应用
trans-1,4-Dichloro-2-butene may be used for the alkylation of adenine to 9-alkylpurines. It can react with diethyl malonate to form vinylcyclopropane derivative. It can also undergo asymmetric allylic alkylation with Grignard reagents in the presence of copper thiophene carboxylate catalyst.
其他说明
85%，残留主要为顺式异构体
警示用语：
Danger
危险分类
Acute Tox. 1 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
WGK
WGK 3
闪点(°F)
127.4 °F
闪点(°C)
53 °C
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
新产品
High Diversity on Simple Substrates: 1, 4?Dihalo?2?butenes and Other Difunctionalized Allylic Halides for Copper?Catalyzed SN2? Reactions.
Falciola C A, et al.
Chemistry?A European Journal , 14(34), 10615-10627 (2008)
Improved selectivity in the preparation of some 1, 1-difunctionalized 3-cyclopentenes. High yield synthesis of 3-cyclopentenecarboxylic acid.
Depres JP and Greene AE.
The Journal of Organic Chemistry, 49(5), 928-931 (1984)
S Phadtare et al.
Journal of medicinal chemistry, 30(2), 437-440 (1987-02-01)
Alkylation of adenine (5a) or 2-amino-6-chloropurine (5b) with excess trans-1,4-dichloro-2-butene (4), effected by K2CO3 in dimethyl sulfoxide or tetra-n-butylammonium fluoride in tetrahydrofuran, led in 90-95% regioselectivity to 9-alkylpurines 6a and 6b. The title compounds 2a and 2b were obtained by
S Phadtare et al.
Nucleic acids symposium series, (18)(18), 25-28 (1987-01-01)
Reaction of adenine (1a) or cytosine (1b) with excess 1,4-dichloro-2-butyne catalyzed by K2CO3 in (CH3)2SO gave the 4-chloro-2-butynyl derivatives 2a and 2b. The latter were converted to the 4-hydroxy-2-butynyl compounds 3a and 3b by refluxing in 0.1 M HCl. Isomerization
L S Mullin et al.
Drug and chemical toxicology, 23(3), 403-417 (2000-08-26)
This study was conducted to elucidate the time- and dose-response relationships of long-term, low-level 1,4-dichlorobutene-2 (DCB) inhalation exposure to nasal tumor induction in rats. Male Crl:CD BR rats were exposed 6 hours per day, 5 days week to 0, 0.1
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