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质量水平
检测方案
95%
形式
liquid
折射率
n20/D 1.447 (lit.)
bp
130-133 °C/750 mmHg (lit.)
密度
1.56 g/mL at 25 °C (lit.)
储存温度
2-8°C
SMILES字符串
CC(=O)OCBr
InChI
1S/C3H5BrO2/c1-3(5)6-2-4/h2H2,1H3
InChI key
NHYXMAKLBXBVEO-UHFFFAOYSA-N
一般描述
人们在体外研究了溴甲基乙酸酯与 O(6)-烷基鸟嘌呤-DNA 烷基转移酶(DNA 修复蛋白)的相互作用。
应用
乙酸溴甲酯用于合成旋光的环己烯防腐剂,(6R)-6- [N-(2-氯-4-氟苯基)氨磺酰基]环己-1-烯-1-羧酸乙酯[(R)-1:TAK-242)]。它还作为试剂,用在钐二碘化物介导酮和醛转化为 1,2-二乙酸酯的过程中。
警示用语:
Warning
危险分类
Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
Chemical & pharmaceutical bulletin, 54(1), 58-62 (2006-01-06)
Two new synthetic methods were established for the efficient synthesis of optically active cyclohexene antisepsis agent, ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate [(R)-1: TAK-242)]. The first method involved recrystallization from methanol of the diastereomeric mixture (6RS,1'R)-7, obtained by esterification of carboxylic acid 3 with
A direct preparation of 1, 2-diacetates from aldehydes and ketones promoted by samarium diiodide.
Tetrahedron Letters, 32(22), 2433-2436 (1991)
Chemical research in toxicology, 17(6), 742-752 (2004-06-23)
O(6)-Alkylguanine-DNA alkyltransferase (AGT) is a DNA repair protein that removes O(6)-alkylguanine adducts. The interaction of dibromomethane (CH(2)Br(2)) and bromomethyl acetate (BrCH(2)OAc) with AGT was studied in vitro, and the effect of AGT on their toxicity and mutagenicity was investigated using
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