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质量水平
方案
97%
表单
powder
mp
173-175 °C (lit.)
SMILES字符串
Oc1ccccc1\N=N\c2ccccc2O
InChI
1S/C12H10N2O2/c15-11-7-3-1-5-9(11)13-14-10-6-2-4-8-12(10)16/h1-8,15-16H/b14-13+
InChI key
JFEVWPNAOCPRHQ-BUHFOSPRSA-N
一般描述
2,2′-Dihydroxyazobenzene is a small molecule inhibitor of ADP ribosyl cyclase and it attenuates angiotensin (Ang) II-induced hypertrophic responses. 2,2′-Dihydroxyazobenzene is formed during the oxidation of diclofenac by myeloperoxidase/hydrogen peroxide.
应用
2,2′-Dihydroxyazobenzene was used as complexing reagent in determination of aluminum in human serum by ion-pair reversed-phase partition HPLC.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
E Kaneko et al.
Analytical chemistry, 63(20), 2219-2222 (1991-10-15)
An ion-pair reversed-phase partition high-performance liquid chromatography-spectrophotometric method is described for the determination of aluminum in human serum, based on its complexation with 2,2'-dihydroxyazobenzene. The chelate is separated on C18-bonded silica packing by using an aqueous methanol mobile phase containing
Dylan I Mori et al.
Advanced materials interfaces, 7(15) (2021-02-13)
Strategies to engineer surfaces that can enable the selective inhibition of bacterial pathogens while preserving beneficial microbes can serve as tools to precisely edit the microbiome. In the oral microbiome, this selectivity is crucial in preventing the proliferation of cariogenic
G Miyamoto et al.
Chemical research in toxicology, 10(4), 414-419 (1997-04-01)
Diclofenac is associated with a low, but significant, incidence of hepatotoxicity and bone marrow toxicity. It has been suggested that this could be due to a reactive acyl glucuronide. An alternative hypothesis is that an oxidative reactive metabolite could be
Rukhsana Gul et al.
Cardiovascular research, 81(3), 582-591 (2008-08-23)
Here, we report the discovery of a small molecule inhibitor, 2,2'-dihydroxyazobenzene (DAB), of ADP ribosyl cyclase (ADPR-cyclase) and showed that this inhibitor attenuated angiotensin (Ang) II-induced hypertrophic responses. and results The intracellular concentration of free Ca(2+) [Ca(2+)](i) in adult rat
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