286281
吲哚-3-乙酰胺
98%
别名:
3-吲哚乙酰胺, NSC 1969
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关于此项目
经验公式（希尔记法）:
C10H10N2O
化学文摘社编号:
分子量:
174.20
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
212-904-4
MDL number:
产品名称
吲哚-3-乙酰胺, 98%
InChI key
ZOAMBXDOGPRZLP-UHFFFAOYSA-N
InChI
1S/C10H10N2O/c11-10(13)5-7-6-12-9-4-2-1-3-8(7)9/h1-4,6,12H,5H2,(H2,11,13)
SMILES string
NC(=O)Cc1c[nH]c2ccccc12
assay
98%
mp
148-150 °C (lit.)
functional group
amide
Quality Level
Application
吲哚-3-乙酰胺用于合成 [5.5.6.6] 二氮杂环乙烷骨架和吲哚-3-乙酸。
用于合成以下物质的反应物：
- 蛋白激酶 C 的 PET 显像剂
- 抗朊病毒病的潜在药物
- 蛋白激酶C（PKC）抑制剂双吲哚基马来酰亚胺IV
- 糖原合成酶激酶-3ß (GSK-3ß) 抑制剂
- CaMKIId 抑制剂
- VEGF 抑制剂
- JAK3 抑制剂
- NAD + 依赖性组蛋白去乙酰化酶抑制剂
- 人脂肪细胞脂肪酸结合蛋白抑制剂
- 细胞周期蛋白依赖性激酶抑制剂
General description
吲哚-3-乙酰胺是一种生长素前体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Christian O Dimkpa et al.
Applied and environmental microbiology, 78(5), 1404-1410 (2012-01-03)
The beneficial bacterium Pseudomonas chlororaphis O6 produces indole-3-acetic acid (IAA), a plant growth regulator. However, the pathway involved in IAA production in this bacterium has not been reported. In this paper we describe the involvement of the indole-3-acetamide (IAM) pathway
Stephan Pollmann et al.
Phytochemistry, 62(3), 293-300 (2003-03-07)
Acylamidohydrolases from higher plants have not been characterized or cloned so far. AtAMI1 is the first member of this enzyme family from a higher plant and was identified in the genome of Arabidopsis thaliana based on sequence homology with the
Chuntao Yin et al.
Molecular plant-microbe interactions : MPMI, 27(3), 227-235 (2013-12-20)
The plant hormone indole-3-acetic acid (IAA) is best known as a regulator of plant growth and development but its production can also affect plant-microbe interactions. Microorganisms, including numerous plant-associated bacteria and several fungi, are also capable of producing IAA. The
Daiana Duca et al.
Antonie van Leeuwenhoek, 106(1), 85-125 (2014-01-22)
Indole-3-acetic acid (IAA) is an important phytohormone with the capacity to control plant development in both beneficial and deleterious ways. The ability to synthesize IAA is an attribute that many bacteria including both plant growth-promoters and phytopathogens possess. There are
Atsushi Umehara et al.
Organic letters, 16(9), 2526-2529 (2014-04-24)
Total syntheses of leuconodine B, melodinine E, and leuconoxine were accomplished via a divergent route. The [5.5.6.6]diazafenestrane skeleton was constructed from an indole-3-acetamide derivative via DMDO oxidation to hydroxylindolenine, TMSOTf/2,6-lutidine mediated cyclic aminal formation, and diastereoseletive ring-closing metathesis of a
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