推荐产品
质量水平
检测方案
98%
mp
262-264 °C (lit.)
SMILES字符串
CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3
InChI
1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
InChI key
BXNJHAXVSOCGBA-UHFFFAOYSA-N
基因信息
human ... CDC2(983) , CYP2D6(1565)
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一般描述
The combination index (CI, serves as a quantitative indicator of pharmacological interactions) for harmaline/harmine and methylene blue/harmine was studied.
应用
Harmine was used as a donor in the fluorescence resonance energy transfer (FRET) study between harmine and silver nanoparticles (AgNPs).
生化/生理作用
中枢神经系统兴奋剂。
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
Katie L Uhl et al.
Cancer cell international, 18, 82-82 (2018-07-07)
Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxic effects. Harmine is capable of blocking the activities
Dea Shahinas et al.
Journal of medicinal chemistry, 53(9), 3552-3557 (2010-03-31)
Malaria is responsible for 3 million deaths annually. Antimalarial drug resistance is widespread, and few novel, well-defined targets exist. A robotic high throughput screen (HTS) was performed using 4000 small molecules from a natural compound (Spectrum), pharmacologically active (Lopac), and
Vikalp Vishwakarma et al.
Scientific reports, 8(1), 12163-12163 (2018-08-17)
Head and neck squamous cell carcinoma (HNSCC) is associated with low survival, and the current aggressive therapies result in high morbidity. Nutraceuticals are dietary compounds with few side effects. However, limited antitumor efficacy has restricted their application for cancer therapy.
Michael F Santillo et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(3), 403-410 (2014-01-01)
Interactions among monoamine oxidase (MAO) inhibitors in drugs, botanicals, and dietary supplements may lead to unpredictable neurochemical dysfunction due to excessive inhibition or therapeutic invalidation. Often recombinant MAO or brain tissue homogenates have been used to evaluate MAO inhibitors such
Raphaël Frédérick et al.
Journal of medicinal chemistry, 55(14), 6489-6501 (2012-07-10)
To overcome the intrinsic resistance of cancer cells to apoptotic stimuli, we designed and synthesized approximately 50 novel β-carbolines structurally related to harmine. Harmine is known for its anticancer properties and is a DYRK1A inhibitor. Of the synthesized compounds, the
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