InChI
1S/C7H6N2/c1-2-5-9-6-4-8-7(9)3-1/h1-6H
SMILES string
c1ccn2ccnc2c1
InChI key
UTCSSFWDNNEEBH-UHFFFAOYSA-N
assay
99%
form
liquid
refractive index
n20/D 1.626 (lit.)
bp
103 °C/1 mmHg (lit.)
density
1.165 g/mL at 25 °C (lit.)
Quality Level
General description
在 STIB900 小鼠模型中研究了咪唑并 [1,2-a] 吡啶的体内抗锥虫活性。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Martina Hieke et al.
Bioorganic & medicinal chemistry letters, 22(5), 1969-1975 (2012-02-14)
A novel class of 5-lipoxygenase (5-LO) inhibitors characterized by a central imidazo[1,2-a]pyridine scaffold, a cyclohexyl moiety and an aromatic system, is presented. This scaffold was identified in a virtual screening study and exhibits promising inhibitory potential on the 5-LO. Here
Katherine A Abrahams et al.
PloS one, 7(12), e52951-e52951 (2013-01-10)
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB. Through the use of
Enza Palazzo et al.
Neuropharmacology, 58(3), 660-667 (2009-12-01)
The 6-methoxy-2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acid, DM2, exerts anti-absence activity and blocks Cav3.1 channel, a T-type voltage-dependent Ca(2+) channel subtype, in vitro. The current study investigated the effect of intra-ventrolateral periaqueductal grey (VLPAG) administration of DM2 on formalin-induced nocifensive responses in rats. In
Anton J Stasyuk et al.
The Journal of organic chemistry, 77(13), 5552-5558 (2012-06-06)
A short and efficient route to a broad range of imidazo[1,2-a]pyridines from 2-aminopyridines and acetophenones is achieved by a tandem, one-pot process starting with an Ortoleva-King reaction. Optimal conditions for the first step were established after examining various reaction parameters
Joanna M Wisniewska et al.
Biochemical pharmacology, 83(2), 228-240 (2011-10-27)
5-Lipoxygenase (5-LO) is a crucial enzyme of the arachidonic acid (AA) cascade and catalyzes the formation of bioactive leukotrienes (LTs) which are involved in inflammatory diseases and allergic reactions. The pathophysiological effects of LTs are considered to be prevented by
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持