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文件

274623

Sigma-Aldrich

戴斯-马丁氧化剂

97%

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别名:
1,1,1-三(乙酰氧基)-1,1-二氢-1,2-苯碘酰-3-(1H)-酮
经验公式（希尔记法）:
C13H13IO8
CAS号:
87413-09-0
分子量:
424.14
MDL编号:
MFCD00130127
UNSPSC代码:
12352005
PubChem化学物质编号:
24856593
NACRES:
NA.22

质量水平

100

检测方案

97%

反应适用性

reagent type: oxidant

mp

130-133 °C (lit.)

储存温度

−20°C

SMILES字符串

CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc12

InChI

1S/C13H13IO8/c1-8(15)19-14(20-9(2)16,21-10(3)17)12-7-5-4-6-11(12)13(18)22-14/h4-7H,1-3H3

InChI key

NKLCNNUWBJBICK-UHFFFAOYSA-N

相关类别

一般描述

Dess-Martin氧化剂(DMP)是一种高价碘化合物，广泛用作伯/仲醇氧化为醛/酮的温和试剂；酰胺氧化成酰亚胺以及胺脱氢成腈，二硫化物脱氢为砜。也用于将烯烃选择性氧化为环氧化物，作为生产三元环醚的有用反应。DMP还用于将1,2-二醇氧化裂解为醛或酮。可用于合成内酯。

应用

Dess–Martin高碘烷可用作以下反应的氧化剂：
  • 一级和二级醇氧化为醛和酮的反应。
  • 以相应的N-保护β-氨基醇合成N-保护α-氨基醛。
  • 合成乙炔基氧化醛探针（AlkMGO）。
用于将羟基二氢卟酚氧化为二氢卟酚-α-二酮和四酮。

特点和优势

使用 DMP 作为氧化试剂的好处：
  • 较温和的反应条件（室温、中性 pH）
  • 更短的反应时间和更高的产率
  • 高化学选择性
  • 敏感官能团的耐受性和较长的保质期
  • 简化的检查

象形图

Flame over circleExclamation mark
GHS03,GHS07

警示用语：

Danger

危险分类

Eye Irrit. 2 - Ox. Sol. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Jun Wang et al.
Journal of endodontics, 43(1), 109-115 (2016-11-17)
Mutations in the proteinase bone morphogenetic protein-1 (BMP1) were recently identified in patients with osteogenesis imperfecta, which can be associated with type 1 dentinogenesis imperfecta. BMP1 is co-expressed in various tissues and has overlapping activities with the closely related proteinase
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Qingfei Z,et al.
The Journal of Organic Chemistry, 85, 1691-1697 (2019)
Hui Chen et al.
Environmental science and pollution research international, 26(24), 24609-24619 (2019-06-27)
Phthalates (PAEs) in drinking water sources such as the Yangtze River in developing countries had aroused widespread concern. Here, the water, suspended particulate matter (SPM), and sediment samples were collected from 15 sites in wet and dry seasons in Zhenjiang
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MicroRNAs (miRNAs) are post-transcriptional regulators that silence messenger RNAs. Because miRNAs are stable at room temperature and long-lived, they have been proposed as molecular biomarkers to monitor disease and exposure status. While urinary miRNAs have been used clinically as potential
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