质量水平
检测方案
97%
形式
powder
mp
188-191 °C (dec.) (lit.)
溶解性
water: soluble 25 mg/mL, clear, colorless
SMILES字符串
Nc1nncs1
InChI
1S/C2H3N3S/c3-2-5-4-1-6-2/h1H,(H2,3,5)
InChI key
QUKGLNCXGVWCJX-UHFFFAOYSA-N
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一般描述
2-氨基-1,3,4-噻二唑（供体）与 2,3-二氯-5,6-二氰--p -苯醌、-p -氯醌、-o -氯醌、-p -溴苯腈和氯苯胺酸（受体）形成电荷转移络合物 。2-氨基-1,3,4-噻二唑 [氨基噻二唑 (NSC 4728)] 对体内 L1210 腹水细胞 的嘌呤和嘧啶核苷酸池的影响 已有报道 。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
G Y Locker et al.
Cancer treatment reports, 71(6), 649-650 (1987-06-01)
Eighty-three patients with advanced colorectal carcinoma were entered on a phase II trial of weekly iv aminothiadiazole (125 mg/m2) plus daily oral allopurinol (300 mg). There were five partial responses. Median survival of all patients on study was 36 weeks
J A Nelson et al.
Cancer research, 36(4), 1375-1378 (1976-04-01)
The effects of 2-amino-1,3,4-thiadiazole [aminothiadiazole (NSC 4728)] on purine and pyrimidine ribonucleotide pools of L1210 ascites cells in vivo are presented and discussed as they relate to the site of action. Within 1 hr after administration of the drug, the
P F Engstrom et al.
American journal of clinical oncology, 14(1), 33-35 (1991-02-01)
Twenty-three patients with advanced inoperable squamous cell carcinoma of the esophagus were treated with aminothiadiazole (A-TD) 125 mg/m2 weekly plus allopurinol daily in a phase II cooperative group trial. No patients responded to treatment; 17 patients progressed, three showed stable
R Asbury et al.
American journal of clinical oncology, 19(4), 400-402 (1996-08-01)
Aminothiadiazole (NSC 4728) is an analog of the thiadiazoles, a group of drugs that stimulated interest because they do not cause significant myelosuppression and have a unique ability to increase uric acid production unrelated to tissue damage. Previous articles have
R F Asbury et al.
American journal of clinical oncology, 10(5), 380-382 (1987-10-01)
The Eastern Cooperative Oncology Group (ECOG) studied 29 patients with advanced measurable colon cancer who were treated with Aminothiadiazole (NSC #4728) 125 mg/m2 intravenously. Allopurinol 300 mg daily was taken by all patients during treatment. Three patients (12%) demonstrated partial
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