检测方案
96%
bp
130-132 °C/14 mmHg (lit.)
mp
30-32 °C (lit.)
SMILES字符串
ClS(=O)(=O)c1cccs1
InChI
1S/C4H3ClO2S2/c5-9(6,7)4-2-1-3-8-4/h1-3H
InChI key
VNNLHYZDXIBHKZ-UHFFFAOYSA-N
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一般描述
Kinetics of reactions of 2-thiophenesulfonyl chloride with substituted anilines in methanol has been reported. Kinetics of solvolysis of 2-thiophenesulfonyl chloride in binary solvent mixtures has been studied.
应用
2-Thiophenesulfonyl chloride has been used in the preparation of 2-((trans-2-phenyl cyclopropyl)sulfonyl)thiophene.
警示用语:
Danger
危险声明
危险分类
Skin Corr. 1B
WGK
WGK 3
闪点(°F)
235.4 °F
闪点(°C)
113 °C
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
2-(trans-. beta.-Styrylsulfonyl)-and 2-((trans-2-phenylcyclopropyl) sulfonyl) thiophene.
The Journal of Organic Chemistry, 37(14), 2354-2355 (1972)
Reaction kinetics of 3-thiophenesulfonyl chloride with anilines in methanol.
The Journal of Organic Chemistry, 39(12), 1689-1691 (1974)
International journal of molecular sciences, 9(5), 914-925 (2009-03-28)
Specific rates of solvolysis in hydroxylic solvents available for the solvolysis of 2-thiophenesulfonyl chloride and phenylmethanesulfonyl chloride are supplemented by determining the values in fluoroalcohol-containing solvents. The data sets are then correlated using the extended Grunwald-Winstein equation. For both substrates
Bioorganic & medicinal chemistry, 22(17), 4968-4997 (2014-07-22)
TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and acetamido moieties at
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