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Merck
CN

255335

Sigma-Aldrich

2-噻酚磺酰氯

96%

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About This Item

经验公式(希尔记法):
C4H3ClO2S2
CAS号:
分子量:
182.65
Beilstein:
123536
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

检测方案

96%

bp

130-132 °C/14 mmHg (lit.)

mp

30-32 °C (lit.)

SMILES字符串

ClS(=O)(=O)c1cccs1

InChI

1S/C4H3ClO2S2/c5-9(6,7)4-2-1-3-8-4/h1-3H

InChI key

VNNLHYZDXIBHKZ-UHFFFAOYSA-N

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一般描述

Kinetics of reactions of 2-thiophenesulfonyl chloride with substituted anilines in methanol has been reported. Kinetics of solvolysis of 2-thiophenesulfonyl chloride in binary solvent mixtures has been studied.

应用

2-Thiophenesulfonyl chloride has been used in the preparation of 2-((trans-2-phenyl cyclopropyl)sulfonyl)thiophene.

象形图

Corrosion

警示用语:

Danger

危险声明

危险分类

Skin Corr. 1B

WGK

WGK 3

闪点(°F)

235.4 °F

闪点(°C)

113 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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2-(trans-. beta.-Styrylsulfonyl)-and 2-((trans-2-phenylcyclopropyl) sulfonyl) thiophene.
Goralski CT.
The Journal of Organic Chemistry, 37(14), 2354-2355 (1972)
Reaction kinetics of 3-thiophenesulfonyl chloride with anilines in methanol.
Arcoria A, et al.
The Journal of Organic Chemistry, 39(12), 1689-1691 (1974)
Malcolm J D'Souza et al.
International journal of molecular sciences, 9(5), 914-925 (2009-03-28)
Specific rates of solvolysis in hydroxylic solvents available for the solvolysis of 2-thiophenesulfonyl chloride and phenylmethanesulfonyl chloride are supplemented by determining the values in fluoroalcohol-containing solvents. The data sets are then correlated using the extended Grunwald-Winstein equation. For both substrates
Radoslaw Laufer et al.
Bioorganic & medicinal chemistry, 22(17), 4968-4997 (2014-07-22)
TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and acetamido moieties at

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