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About This Item
线性分子式:
CH3C(=NH)OCH3 · HCl
CAS号:
分子量:
109.55
Beilstein:
3671581
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
推荐产品
等级
technical grade
质量水平
mp
105 °C (dec.) (lit.)
官能团
amine
储存温度
2-8°C
SMILES字符串
Cl.COC(C)=N
InChI
1S/C3H7NO.ClH/c1-3(4)5-2;/h4H,1-2H3;1H
InChI key
WHYJXXISOUGFLJ-UHFFFAOYSA-N
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一般描述
Methyl acetimidate hydrochloride is an inhibitor of N-methylation of phosphatidylethanolamine. It also prevents the stimulation of purified cardiac sarcolemmal vesicles Ca2+-pump activities.
应用
Methyl acetimidate hydrochloride has been used in pre-crystallization chemical modification of lysine residues.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
T L Chao et al.
The Journal of biological chemistry, 256(11), 5324-5326 (1981-06-10)
The appearance of an immune response in some sickle cell anemia patients to reinfused autologous erythrocytes which had been treated with methyl acetimidate (Gabuzda, T. G., Chao, T. L., Berenfeld, M. R., and Gelbart, T. (1980) Blood 56, 1041--1047) was
T L Chao et al.
Hemoglobin, 5(1), 47-72 (1981-01-01)
The contribution of the high molecular weight hemoglobin (HMW Hb) to the antisickling effect produced by treatment of sickle cell erythrocytes with methyl acetimidate (MAI) was investigated. Erythrocytes obtained from sickle cell anemia and normal individuals were incubated with varying
Activation/inactivation of human angiotensin I converting enzyme following chemical modifications of amino groups near the active site.
J A Weare
Biochemical and biophysical research communications, 104(4), 1319-1326 (1982-02-26)
P K Ganguly et al.
Biochemical and biophysical research communications, 130(1), 472-478 (1985-07-16)
Incubation of cardiac sarcoplasmic reticulum (SR) in the presence of S-adenosyl-L-methionine, a methyl donor for the enzymatic N-methylation of phosphatidylethanolamine, increased Ca2+-stimulated ATPase activity. The increase in Ca2+-ATPase activity was not due to changes in the affinity for Ca2+ and
V B Richardson et al.
Mutation research, 180(1), 121-129 (1987-09-01)
The cytogenetic effects of methyl acetimidate (MAI), a lysine-specific protein crosslinking reagent, were investigated using human peripheral lymphocytes in culture. Lymphocytes were treated with the chemical either prior to PHA exposure or 2-3 days following mitogenic stimulation and assessed for
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