244309
β-咔啉-3-羧酸乙酯
97%
别名:
β-CCE, 9H-吡啶并[3,4-b]吲哚-3-羧酸乙酯
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关于此项目
经验公式（希尔记法）:
C14H12N2O2
化学文摘社编号:
分子量:
240.26
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
Form:
solid
InChI
1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3
SMILES string
CCOC(=O)c1cc2c(cn1)[nH]c3ccccc23
InChI key
KOVRZNUMIKACTB-UHFFFAOYSA-N
assay
97%
form
solid
mp
228-230 °C (lit.)
functional group
ester
Gene Information
human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRG2(2566)
rat ... Gabra2(29706)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Stuart T Leonard et al.
Behavioural pharmacology, 20(1), 33-44 (2009-01-31)
Despite the knowledge that gamma-aminobutyric acid(A) modulators can affect learning and memory, their capacity for disrupting each of these complex processes is rarely compared, and often mistakenly assumed to occur with identical potency. For these reasons, the effects of flunitrazepam
T Shimada et al.
General pharmacology, 26(1), 205-210 (1995-01-01)
1. We devised a new light/dark transition apparatus, recorded transitions, % time animals spent outside the dark chambers (% time) and locomotor activity, and evaluated this apparatus by testing anxiolytics, non-anxiolytic drugs and putative anxiogenic drugs in mice. 2. Diazepam
J Auta et al.
The Journal of pharmacology and experimental therapeutics, 280(1), 316-325 (1997-01-01)
A multiple schedule of repeated acquisition and performance of conditional discriminations was used to characterize the effects of two negative allosteric modulators of the gamma-aminobutyric acid (GABAA) receptor (ethyl beta-carboline-3-carboxylate [beta-CCE] and N-methyl-beta-carboline-3-carboxamide [FG-7142]), a hallucinogenic beta-carboline derivative (harmine), a
J G Wettstein et al.
Pharmacology, biochemistry, and behavior, 44(3), 633-641 (1993-03-01)
The respiratory and behavioral effects of the benzodiazepine receptor (BZR) inverse agonist ethyl-beta-carboline-3-carboxylate (beta-CCE) were determined alone and in combination with buspirone, lorazepam, flumazenil, and SR 95195 in rhesus monkeys. For the respiratory studies, one group of monkeys inhaled either
D B Williams et al.
Molecular pharmacology, 58(5), 1129-1136 (2000-10-20)
Benzodiazepine binding to gamma-aminobutyric acid type A (GABA(A)) receptors allosterically modulates GABA binding and increases the currents induced by submaximal GABA concentrations. Benzodiazepines induce conformational changes in the GABA-binding site in the extracellular domain, but it is uncertain whether these
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