244309
β-咔啉-3-羧酸乙酯
97%
别名:
β-CCE, 9H-吡啶并[3,4-b]吲哚-3-羧酸乙酯
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关于此项目
经验公式（希尔记法）:
C14H12N2O2
化学文摘社编号:
分子量:
240.26
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
Form:
solid
InChI
1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3
SMILES string
CCOC(=O)c1cc2c(cn1)[nH]c3ccccc23
InChI key
KOVRZNUMIKACTB-UHFFFAOYSA-N
assay
97%
form
solid
mp
228-230 °C (lit.)
functional group
ester
Gene Information
human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRG2(2566)
rat ... Gabra2(29706)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Beta-carboline-3-carboxylic acid ethyl ester: a lead for new psychotropic drugs.
R Schmiechen et al.
Psychopharmacology series, 11, 7-15 (1993-01-01)
B Elgoyhen et al.
The Journal of pharmacology and experimental therapeutics, 261(2), 534-539 (1992-05-01)
The effects of two beta-carbolines, methyl 6,7-dimethoxy-4-ethyl-beta- carboline-3-carboxylate (DMCM) and ethyl beta-carboline-3-carboxylate (beta CCE) were assayed on rat aortic rings precontracted with different agonists. The beta-carbolines tested induced a concentration-dependent (2-200 microM) relaxation of aortic rings precontracted with 30 mM
M Katsura et al.
European journal of pharmacology, 298(1), 71-77 (1996-02-29)
Effect of exposure of primary cultured cerebral cortical neurons to ethyl beta-carboline-3-carboxylate (beta-CCE) on the function of benzodiazepine receptors was studied. Exposure of neurons to beta-CCE (0.1-10 microM) decreased the binding of [3H]flunitrazepam to extensively washed membrane fractions in a
L R Gerak et al.
Pharmacology, biochemistry, and behavior, 61(4), 375-380 (1998-11-05)
This study examined changes in ventilation produced by negative gamma-aminobutyric acid(A) (GABA(A)) modulators in rhesus monkeys. The effects of Ro 15-4513, beta-CCE and beta-CCM were examined in four rhesus monkeys breathing air or 5% CO2 in air. When monkeys breathed
B K Koe et al.
European journal of pharmacology, 90(1), 97-102 (1983-05-20)
Ethyl beta-carboline-3-carboxylate (beta CCE), a benzodiazepine antagonist, was found to increase basal levels of cyclic GMP in rat cerebellum. beta CCE also augmented the elevation of cyclic GMP concentrations induced by isoniazid, in contrast to diazepam which blocked this effect
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