推荐产品
质量水平
方案
≥99%
表单
powder
mp
226-229 °C (lit.)
溶解性
acetone: 1g in 12mL(lit.)
alcohol: 1g in 31mL(lit.)
boiling water: 1g in 25mL(lit.)
water: 1g in 25mL(lit.)
SMILES字符串
O=C1NS(=O)(=O)c2ccccc12
InChI
1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
InChI key
CVHZOJJKTDOEJC-UHFFFAOYSA-N
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一般描述
人们研究了人工甜味剂——糖精（2-磺基苯甲酰亚胺）的生物降解。人们还研究了它的致癌潜力。
应用
- 具有增强的理化性质和体内吸收的加巴喷丁-糖精共晶，配制成口崩片：这项研究介绍了加巴喷丁-糖精共晶的制剂，证明了其溶解度和吸收的改善，这有利于药物应用（Soliman等人，2020年，doi：10.1080/10837450.2019.1687521）。
- 通过与糖精共非晶态制备来提高伊布替尼的溶解度、溶出度和生物利用度：该研究重点是通过与糖精的共非晶态制备来提高伊布替尼的生物利用度，这对于癌症治疗具有重要意义（Shi等人，2019，doi：10.1016/J.xphs.2019.04.031）。
生化/生理作用
哺乳动物的甜促味剂。有人提出，果蝇具有葡萄糖特异性甘油味觉受体结合位点。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
N H Tran et al.
Bioresource technology, 161, 40-46 (2014-04-01)
The biodegradation of the six artificial sweetening agents including acesulfame (ACE), aspartame (ASP), cyclamate (CYC), neohesperidindihydrochalcone (NHDC), saccharin (SAC), and sucralose (SUC) by nitrifying activated sludge was first examined. Experimental results showed that ASP and NHDC were the most easily
Hellmuth Lilienthal et al.
Toxicology, 311(1-2), 52-60 (2013-02-14)
Many chemicals are known to exhibit endocrine activity and affect reproductive functions in vertebrates and invertebrates. Endocrine effects include influences on sexual differentiation of the brain during development and reproductive and non-reproductive behavior in adult offspring. We previously demonstrated that
Hugh P Morgan et al.
The Biochemical journal, 448(1), 67-72 (2012-08-22)
PYK (pyruvate kinase) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems biology context has been hampered by the lack of specific high-affinity small-molecule
Katharine J Tuerke et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13709-13717 (2012-10-05)
A taste associated with emetic drugs produces conditioned disgust reactions in rats (predominantly gaping), unlike nonemetic drugs that can still produce conditioned taste avoidance but not conditioned disgust. That difference suggests nausea is a prerequisite for learning disgust reactions to
Rino Ragno et al.
Journal of medicinal chemistry, 50(6), 1241-1253 (2007-02-28)
The screening of the inhibition capabilities of dye-like small molecules from a focused library against both human PRMT1 and Aspergillus nidulans RmtA is reported as well as molecular modeling studies (homology modeling, molecular docking, and 3-D QSAR) of the catalytic
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