所有图片(1)
About This Item
线性分子式:
ClCOOCH2Cl
CAS号:
分子量:
128.94
Beilstein:
506426
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
推荐产品
质量水平
方案
≥98.0% (GC)
表单
liquid
折射率
n20/D 1.428
沸点
107-108 °C (lit.)
密度
1.450 g/mL at 20 °C
官能团
chloro
储存温度
2-8°C
SMILES字符串
ClCOC(Cl)=O
InChI
1S/C2H2Cl2O2/c3-1-6-2(4)5/h1H2
InChI key
JYWJULGYGOLCGW-UHFFFAOYSA-N
应用
氯甲酸氯甲基酯作为关键反应物用于合成：
- 双氯芬酸和氟芬那酸的新型氨基羰基氧甲酯
- 环孢菌素 A 的高水溶性单甲氧基聚乙二醇前体药物
- 3-乙酰氧基甲氧羰基-1-芳基-3-甲基三氮烯系列
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Inhalation - Skin Corr. 1B
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
203.0 °F - closed cup
闪点(°C)
95 °C - closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
E Carvalho et al.
Bioorganic & medicinal chemistry, 8(7), 1719-1725 (2000-09-08)
A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, and (iii) either the silver carboxylate or the carboxylic acids in the presence of silver carbonate. The hydrolysis
Hoon Cho et al.
Archives of pharmacal research, 27(6), 662-669 (2004-07-31)
The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbonate at the 3'-positions of CsA with chloromethyl chloroformate, in the presence of a base to
Lina Ribeiro et al.
Archiv der Pharmazie, 340(1), 32-40 (2007-01-09)
Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O-->N intramolecular acyl transfer from the carbamate conjugate base. Novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid containing amino acid
Keivan Sadrerafi et al.
Drug design, development and therapy, 12, 987-995 (2018-05-08)
Our previous study indicated that carborane containing small-molecule 1-(hydroxymethyl)-7-(4'-(trans-3″-(3'″-pyridyl)acrylamido)butyl)-1,7-dicarbadodecaborane (hm-MC4-PPEA), was a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt). Nampt has been shown to be upregulated in most cancers and is a promising target for the treatment of many different types
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门