质量水平
检测方案
95%
形式
solid
反应适用性
reaction type: click chemistry
mp
272-273 °C (lit.)
SMILES字符串
OC(=O)c1ccc(cc1)S(F)(=O)=O
InChI
1S/C7H5FO4S/c8-13(11,12)6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)
InChI key
DJUJJHDCOUPERR-UHFFFAOYSA-N
一般描述
4-（氟磺酰基）苯甲酸是一种异源生物底物类似物，与大鼠肝谷胱甘肽S-转移酶的4-4同工酶孵育后会导致该酶的时间依赖性失活。
应用
4-（氟磺酰基）苯甲酸用作二聚体猪肺pi类谷胱甘肽S-转移酶的亲和标记。
警示用语：
Danger
危险声明
危险分类
Skin Corr. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Lisa L Moore et al.
Journal of proteome research, 3(6), 1184-1190 (2004-12-15)
Proteins that bind ATP and GTP are important cellular components. We developed an immunological approach to selectively tag nucleotide-binding proteins based on the use of 5'-[4-(fluorosulfonyl)benzoyl]adenosine and 5'-[4-(fluorosulfonyl)benzoyl]guanosine affinity tags and an antibody against 4-(sulfonyl)benzoate. Detection follows affinity labeling, gel
J Wang et al.
Protein science : a publication of the Protein Society, 5(6), 1032-1042 (1996-06-01)
Reaction of rat liver glutathione S-transferase, isozyme 1-1, with 4-(fluorosulfonyl)benzoic acid (4-FSB), a xenobiotic substrate analogue, results in a time-dependent inactivation of the enzyme to a final value of 35% of its original activity when assayed at pH 6.5 with
N E Pettigrew et al.
Archives of biochemistry and biophysics, 364(1), 107-114 (1999-03-24)
The compound 4-(fluorosulfonyl)benzoic acid (4-FSB) functions as an affinity label of the dimeric pig lung pi class glutathione S-transferase yielding a completely inactive enzyme. Protection against inactivation is provided by glutathione-based ligands, suggesting that the reaction target is near or
J J Barycki et al.
Biochemistry, 32(48), 13002-13011 (1993-12-07)
Incubation of 4-(fluorosulfonyl)benzoic acid (4-FSB), a xenobiotic substrate analogue, with the 4-4 isozyme of rat liver glutathione S-transferase at pH 7.5 and 25 degrees C results in a time-dependent inactivation of the enzyme. The rate of inactivation exhibits a nonlinear
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