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质量水平
方案
99%
mp
90-92 °C (lit.)
溶解性
water: soluble 50 mg/mL, clear, colorless to faintly yellow
密度
1.611 g/mL at 25 °C (lit.)
SMILES字符串
NS(N)(=O)=O
InChI
1S/H4N2O2S/c1-5(2,3)4/h(H4,1,2,3,4)
InChI key
NVBFHJWHLNUMCV-UHFFFAOYSA-N
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一般描述
磺酰胺，一种与格氏试剂相容的极性非质子溶剂，可用作医学化学中的官能团。
应用
磺胺被用于合成以下物质：
- ArCH=NSO2NH2型席夫碱
- 1H,3H-2,1,3-苯并噻二嗪-4-酮-2,2-二氧化物（BTDD）
- 在一项PPARα激活的研究中，合成油酰乙醇胺类似物的磺酰胺类似物。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Bacterial cleavage of nitrogen to sulfone bonds in sulfamide and 1H-2, 1, 3-benzothiadiazin-4 (3H)-one 2, 2-dioxide: formation of 2-nitrobenzamide by Gordonia sp.
Rein U and Cook AM.
FEMS Microbiology Letters, 172(2), 107-113 (1999)
Sulfamides and sulfonamides as polar aprotic solvents
Herman R G et al.
The Journal of Organic Chemistry, 52, 479-483 (1987)
Anomeric effects in sulfamides
Eric H et al.
The Journal of Physical Chemistry A, 120, 3677-3682 (2016)
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 19(4), 1155-1158 (2009-01-09)
The membrane-associated mouse isozyme of carbonic anhydrase XV (mCA XV), has been investigated for its interaction with anion inhibitors. mCA XV is an isoforms possessing a very particular inhibition profile by anions, dissimilar to that of all other mammalian CAs
Jean-Yves Winum et al.
Bioorganic & medicinal chemistry letters, 15(9), 2353-2358 (2005-04-20)
A small library of N-hydroxysulfamides was synthesized by an original approach in order to investigate whether this zinc-binding function is efficient for the design of inhibitors targeting the cytosolic (hCA I and II) and transmembrane, tumor-associated (hCA IX and XII)
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