202673
氧化砷(III)
99.995% trace metals basis, powder
别名:
ATO, 三氧化二砷；, 三氧化二砷, 亚砷酸
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关于此项目
经验公式（希尔记法）:
As2O3
化学文摘社编号:
分子量:
197.84
UNSPSC Code:
12161600
eCl@ss:
38080102
PubChem Substance ID:
NACRES:
NA.22
EC Number:
215-481-4
MDL number:
产品名称
氧化砷(III), 99.995% trace metals basis
SMILES string
O=[As]O[As]=O
InChI
1S/As2O3/c3-1-5-2-4
InChI key
IKWTVSLWAPBBKU-UHFFFAOYSA-N
assay
99.995% trace metals basis
form
powder
reaction suitability
core: arsenic
reagent type: catalyst
Quality Level
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Application
- 电化学检测应用：一项关于包含功能化碳纳米纤维的镧基钙钛矿的研究强调了三氧化二砷在水和食品样品中洛克沙砷（roxarsone）电化学检测的用途，提供了一种提高安全性和环境监测方法 (John Felix MA et al., 2024）。
- 癌症研究中的抗增殖作用：该研究显示了三氧化二砷与二甲双胍联用对KG1a细胞增殖的抑制作用，表明其在抗肿瘤策略制定方面的潜在效用(Huang-Li WH et al., 2024）。
- 环境修复：这篇关于氧化锰基除砷材料的综述讨论了三氧化二砷在环境修复中的应用，重点介绍了砷净化技术的有效性和进展 （Younas M et al., 2024）。
General description
氧化砷（ATO）是一种无机形式的砷，可用作治疗急性早幼粒细胞白血病（APL）患者的治疗化合物。目前正在开发许多药物传递方法，利用纳米技术克服由于快速从血液中清除而导致生物利用度差的问题。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Skin Corr. 1B - STOT RE 1
target_organs
Respiratory system,Cardio-vascular system,Gastrointestinal tract
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
此项目有
A facile route to core?shell nanoparticulate formation of arsenic trioxide for effective solid tumor treatment.
Zhang Z, et al.
Nanoscale, 8(7), 4373-4380 (2016)
Silica nanovehicles endow arsenic trioxide with an ability to effectively treat cancer cells and solid tumors.
Zhao Z, et al.
Journal of Materials Chemistry, 2(37), 6313-6323 (2014)
Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers.
Akhtar A, et al.
Journal of biomedical research, 31(3), 177-177 (2017)
Ruoshi Xu et al.
Bone research, 6, 33-33 (2018-11-28)
How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal
Liangchun Hao et al.
Journal of pediatric hematology/oncology, 35(2), e67-e70 (2013-02-16)
The aim of this study was to investigate the hepatotoxicity induced by arsenic trioxide (As2O3) at a therapeutic dose for pediatric acute promyelocytic leukemia (APL). A total of APL patients received As2O3 treatment by IV drip. Hepatotoxicity was monitored based
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