所有图片(3)
About This Item
线性分子式:
POCl3
CAS号:
分子量:
153.33
EC 号:
MDL编号:
UNSPSC代码:
12352101
PubChem化学物质编号:
NACRES:
NA.22
方案:
99%
沸点:
105.8 °C (lit.)
蒸汽压:
104 mmHg ( 50 °C)
28 mmHg ( 20 °C)
28 mmHg ( 20 °C)
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蒸汽密度
5.3 (vs air)
质量水平
蒸汽压
104 mmHg ( 50 °C)
28 mmHg ( 20 °C)
产品线
ReagentPlus®
方案
99%
表单
liquid
pH值（酸碱度）
1 (20 °C)
沸点
105.8 °C (lit.)
mp
1.25 °C (lit.)
密度
1.645 g/mL at 25 °C (lit.)
官能团
phosphine oxide
SMILES字符串
ClP(Cl)(Cl)=O
InChI
1S/Cl3OP/c1-5(2,3)4
InChI key
XHXFXVLFKHQFAL-UHFFFAOYSA-N
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应用
Phosphorus(V) oxychloride (POCl3) is a chlorinating agent that reacts with dimethylformamide (DMF) to form Vilsmeier reagent for Vilsmeier-Haack formylation reactions.
It can also be used as a reagent in the synthesis of:
It can also be used as a reagent in the synthesis of:
- Quinazolin-4(3H)-one derivatives from 2-aminobenzamides via in situ preparation of Vilsmeier reagent.
- Substituted 1-arylseleno-4-halo-2-enes by treating conjugated dienes with arylselenenamides.
- 3-methylthioimidazo[1,2-a]pyridines and imidazo-fused heterocycles in the presence of DMSO.
包装
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法律信息
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1A - STOT RE 1 Inhalation
靶器官
Respiratory Tract
补充剂危害
储存分类代码
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
监管及禁止进口产品
DMSO-POCl3: a reagent for methylthiolation of imidazo [1, 2-a] pyridines and other imidazo-fused heterocycles
Patil SM, et al.
Tetrahedron, 69(38), 8255-8262 (2013)
Arylselenenation of conjugated dienes by arylselenenamides in the presence of phosphorus (V) oxyhalides
Antipin RL, et al.
Tetrahedron Letters, 48(4), 729-731 (2007)
Regioselective formylation of pyrazolo [3, 4-b] pyridine and pyrazolo [1, 5-a] pyrimidine systems using Vilsmeier?Haack conditions.
Quiroga J
Tetrahedron Letters, 49(17), 2689-2691 (2008)
Vilsmeier Reagent: An Efficient Reagent for the Transformation of 2-Aminobenzamides into Quinazolin-4 (3 H)-one Derivatives.
Farzipour S, et al.
Synthetic Communications, 44(4), 481-487 (2014)
Vilsmeier-Haack formylation of 2-(1H-pyrazol-1-yl) ethanol and its methyl derivatives.
Rstakyan VI, et al.
Russ. J. Gen. Chem., 85(5), 1191-1193 (2015)
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