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Merck
CN

20021

Sigma-Aldrich

3-叔丁基-4-羟基苯甲醚

≥98% (sum of isomers, GC), ≤10% 2-BHA basis (GC)

别名:

2-叔丁基-4-甲氧基苯酚, 3-BHA, BHA

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About This Item

经验公式(希尔记法):
C11H16O2
CAS号:
分子量:
180.24
Beilstein:
1867499
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

质量水平

方案

≥98% (sum of isomers, GC)

表单

solid

组成

2-BHA, ≤10% GC
3-BHA, ≥90% GC

杂质

≤1% 4-hydroxyanisole

灼烧残渣

≤0.05%

mp

48-63 °C

溶解性

ethanol: soluble 1 g/10 mL, clear, colorless to faint yellow or tan

SMILES字符串

COc1ccc(O)c(c1)C(C)(C)C

InChI

1S/C11H16O2/c1-11(2,3)9-7-8(13-4)5-6-10(9)12/h5-7,12H,1-4H3

InChI key

MRBKEAMVRSLQPH-UHFFFAOYSA-N

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一般描述

研究了 3--叔 -丁基-4-羟基苯甲醚在酞菁镍(作为电子媒介体)修饰的聚合物电极上的伏安行为

应用

  • 调节间充质干细胞中的Smad信号通路:3-叔丁基-4-羟基苯甲醚通过调节Smad信号通路干扰C3H10T1/2间充质干细胞向褐色脂肪细胞的分化,揭示它在肥胖症和代谢综合征研究中的潜在应用(Wang et al., 2023)。

象形图

Environment

危险声明

预防措施声明

危险分类

Aquatic Chronic 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

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访问文档库

C de la Fuente et al.
Talanta, 49(2), 441-452 (2008-10-31)
The voltammetric behaviour of the antioxidants 3-tert-butyl-4-hydroxyanisole (BHA) and tert-butylhydroquinone (TBHQ), at a polymer electrode modified with nickel phthalocyanine as electron mediator, is described, and an electroanalytical method for the determination of these antioxidants based on their electrochemical oxidation on
A Matsuoka et al.
Mutation research, 241(2), 125-132 (1990-06-01)
The mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and its metabolites was investigated in the reverse mutation assay using S. typhimurium strains and the chromosomal aberration test in vitro using a Chinese hamster fibroblast cell line, CHL. BHA, tert-butylhydroquinone (BHQ), tert-butylquinone (BQ) and
K Tajima et al.
Drug metabolism and disposition: the biological fate of chemicals, 20(6), 816-820 (1992-11-01)
3-Tert-butyl-4-hydroxyanisole (3-BHA) was metabolized in the presence of horseradish peroxidase and hydrogen peroxide to 2-tert-butyl-p-benzoquinone (TBQ), 2,3-epoxy-5-tert-butyl-1,4-benzoquinone (TBQ-epoxide), and two known dimers. The formation of TBQ from 3-BHA required both horseradish peroxidase and hydrogen peroxide. When 2.5 mM 3-BHA was
K Tajima et al.
Drug metabolism and disposition: the biological fate of chemicals, 19(6), 1028-1033 (1991-11-01)
After ip administration of 3-tert-butyl-4-hydroxyanisole (3-BHA) to rats, two previously undocumented metabolites 2-tert-butyl-5-methylthiohydroquinone (TBHQ-5-SMe) and 2-tert-butyl-6-methylthiohydroquinone (TBHQ-6-SMe) were identified in the urine by comparison with the authentic samples by GC/MS. In addition to these metabolites, 3-tert-butyl-4,5-dihydroxyanisole was also detected in
M G Salgo et al.
Archives of biochemistry and biophysics, 333(2), 482-488 (1996-09-15)
Peroxynitrite is a strong oxidant that reacts with a variety of biomolecules in vivo and in vitro. When rat thymocytes in phosphate buffer are exposed to 25 microM peroxynitrite for 10 min, DNA single strand breaks (SSB) can be detected.

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