推荐产品
方案
97%
表单
solid
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
沸点
128-132 °C/12 mmHg (lit.)
官能团
phenyl
SMILES字符串
CN1CCC(=CC1)c2ccccc2
InChI
1S/C12H15N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-7H,8-10H2,1H3
InChI key
PLRACCBDVIHHLZ-UHFFFAOYSA-N
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生化/生理作用
Dopaminergic neurotoxin.
警告
Reportedly causes a severe and irreversible Parkinsonism condition in humans and monkeys. New Engl. J. Med. 1983, 309, 310. Science 1983, 219, 979. ibid. 1984, 224, 1083, 1451. ibid. 1984, 225, 529. J. Med. Chem. 1985, 28, 997.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral - STOT SE 1
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
235.4 °F - closed cup
闪点(°C)
113 °C - closed cup
法规信息
新产品
Yuanyuan Liu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 40(1-2), 18-26 (2016-11-15)
Development of effective therapeutic drugs for Parkinson's disease is in great need. During the progression of Parkinson's disease, Rho-associated protein kinase 2 (ROCK2) is activated to promote neurodegeneration. Hydrogen sulfide (H2S) has a neuroprotective effect during the neural injury of
Yan Liu et al.
Aging, 11(14), 5008-5034 (2019-07-18)
Parkinson's disease (PD) is a common neurodegenerative disease, featured by motor deficits and non-motor symptoms such as cognitive impairment, and malfunction of gamma-aminobutyric acid (GABA) mediated inhibitory transmission plays an important role in PD pathogenesis. The ginsenoside Rb1 molecule, a
Hideaki Matsui et al.
Journal of neural transmission (Vienna, Austria : 1996), 125(1), 25-33 (2017-08-05)
Parkinson's disease is a neurodegenerative disorder that involves movement discloses, degeneration of dopaminergic neurons, and presence of cytoplasmic inclusion bodies. Various animal models have been developed and small fish including zebrafish and medaka fish have recently been employed as a
Adjia Hamadjida et al.
Journal of neural transmission (Vienna, Austria : 1996), 125(9), 1355-1360 (2017-12-17)
Trazodone is a clinically available anti-depressant that exhibits affinity for serotonin 1A and 2A receptors, as well as for alpha-adrenoceptors, suggesting that it may be useful to treat L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia and psychosis that are encountered in advanced Parkinson's disease
Gejuan Zhang et al.
Life sciences, 232, 116600-116600 (2019-06-30)
Neuroinflammation is one of the significant neuropathological conditions in Parkinson's disease (PD) which is due to microglial and astrocytes activation leads to progressive dopaminergic neuronal loss. To date, Current PD drugs offers only symptomatic relief with adverse effects and lack
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