所有图片(2)
About This Item
经验公式（希尔记法）:
C6H7ClIN
CAS号:
分子量:
255.48
Beilstein:
3572320
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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质量水平
方案
97%
mp
200 °C (dec.) (lit.)
官能团
chloro
SMILES字符串
[I-].C[n+]1ccccc1Cl
InChI
1S/C6H7ClN.HI/c1-8-5-3-2-4-6(8)7;/h2-5H,1H3;1H/q+1;/p-1
InChI key
ABFPKTQEQNICFT-UHFFFAOYSA-M
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一般描述
2-氯-1-甲基吡啶碘化物（Mukaiyama试剂）是有机合成中的常用试剂，用于活化醇的羟基和羧酸。它可用于以相应的羧酸合成酯、内酯、酰胺、内酰胺和烯酮的衍生物。由于其毒性低、反应条件简单、价格比EDC便宜，它还可用作肽合成中的高效偶联剂。
应用
2-氯-1-甲基吡啶碘化物（CMPI）可用作：
- 脱水剂，用于将各种醛肟转化为腈，醇转化为硫氰酸烷基酯。
- 交联剂，用于制备用于生物医学应用的可生物降解交联透明质酸膜和明胶膜。
- 缩合剂，用于以β氨基酸合成各种β内酰胺。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
W Keese et al.
Biological chemistry Hoppe-Seyler, 366(12), 1093-1095 (1985-12-01)
2-Chloro-1-methylpyridinium iodide is a coupling reagent for peptide synthesis. By its use different peptides were synthesized with protected di- and trifunctional amino acids. While urethan-protected amino acids react free of racemization, the fragment condensation needs N-Hydroxysuccinimide, as shown by the
Chul-Hwan Lee et al.
Molecular cell, 70(3), 422-434 (2018-04-24)
PRC2 is a therapeutic target for several types of cancers currently undergoing clinical trials. Its activity is regulated by a positive feedback loop whereby its terminal enzymatic product, H3K27me3, is specifically recognized and bound by an aromatic cage present in
Efficient Transformation of Aldoximes to Nitriles Using 2-Chloro-1-methylpyridinium Iodide Under Mild Conditions
Lee Kieseung, et al.
Synthetic Communications, 34(10), 1775-1782 (2004)
Tetrahedron Asymmetry, 3, 1455-1455 (1992)
A novel cell support membrane for skin tissue engineering: Gelatin film cross-linked with 2-chloro-1-methylpyridinium iodide
Yeh Ming-kung, et al.
Polymer, 52(4), 996-1003 (2011)
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