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Merck
CN

195413

Sigma-Aldrich

甲基丙烯腈

99%

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别名:
1-Methylethenyl cyanide, 2-Cyano-1-propene, 2-Methyl-2-propenenitrile, 2-Methylpropenenitrile, Isobutenenitrile, Isopropene cyanide, Methacrylnitrile
线性分子式:
CH2=C(CH3)CN
CAS号:
分子量:
67.09
Beilstein:
773708
EC 号:
MDL编号:
UNSPSC代码:
12162002
PubChem化学物质编号:

蒸汽压

64 mmHg ( 20 °C)

检测方案

99%

包含

50 ppm monomethyl ether hydroquinone as inhibitor

折射率

n20/D 1.400 (lit.)

bp

90-92 °C (lit.)

mp

−35.8 °C (lit.)

密度

0.8 g/mL at 25 °C (lit.)

SMILES字符串

CC(=C)C#N

InChI

1S/C4H5N/c1-4(2)3-5/h1H2,2H3

InChI key

GYCMBHHDWRMZGG-UHFFFAOYSA-N

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警示用语:

Danger

危险分类

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Flam. Liq. 2 - Skin Sens. 1 - STOT SE 1

靶器官

Central nervous system

WGK

WGK 2

闪点(°F)

closed cup

闪点(°C)

closed cup

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

监管及禁止进口产品

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Hongbing Wang et al.
Journal of toxicology and environmental health. Part A, 65(7), 523-537 (2002-04-10)
Tissue-specific induction of cytochrome P-450s (CYP) followed by increased in situ bioactivation may contribute to chemical-induced site-specific toxicity. In rats, methacrylonitrile (MAN) is metabolized by cytochrome P-450 2E1 (CYP2E1) to acetone, which is eliminated along with parent MAN in breath.
V Vasanthakumari et al.
Indian journal of biochemistry & biophysics, 34(6), 540-542 (1998-05-22)
MeAN administration (40mg/kg body wt/day (i.e. 1/5 of LD50) resulted in increased levels of lipid peroxidation products, conjugated dienes and lipofuscin-like substances in rat liver. Significant decrease in GSH and a decreased activity of hepatic SOD, CAT and GPx were
T Samikkannu et al.
Toxicology letters, 92(1), 15-20 (1997-06-16)
The effect of methacrylonitrile (MeAN) a cyanogen compound, on various haematological parameters was studied. Administration of MeAN at 100 mg/kg per body weight/day for 7 days resulted in a significant decrease in the red cell count and in the level
National Toxicology Program technical report series, (497)(497), 1-225 (2002-01-24)
Methacrylonitrile is an unsaturated aliphatic nitrile. It is widely used in the preparation of homopolymers and copolymers, elastomers, and plastics and as a chemical intermediate in the preparation of acids, amides, amines, esters, and other nitriles. Methacrylonitrile is also used
B I Ghanayem et al.
Carcinogenesis, 18(4), 675-680 (1997-04-01)
Acrylonitrile (AN) and methacrylonitrile (MAN) are two major industrial nitriles used in the production of plastics and acrylic fibers. Whereas AN is a potent acute toxin and carcinogenic in rats, little is known regarding MAN. Current work is part of

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