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Merck
CN

191892

Sigma-Aldrich

羟丙基纤维素

average Mw ~370,000, powder, 20 mesh particle size (99% through)

别名:

HPC

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About This Item

CAS号:
MDL编号:
UNSPSC代码:
12162002
NACRES:
NA.23

描述

biological oxygen demand (BOD) 14,000 ppm

质量水平

表单

powder

自燃温度

752 °F

分子量

average Mw ~370,000

杂质

<5 wt. %

粒径

20 mesh (99% through)

pH值(酸碱度)

5.0-8.5

界面张力矿物油

12.5 dyn/cm, 0.1 wt. % in H2O (vs. mineral oil)

粘度

150-400 cP, 2 wt. % in H2O(25 °C, Brookfield, spindle #2) (60 rpm)(lit.)

溶解性

H2O: insoluble (above 45 °C)
polar organic solvents: soluble

密度

0.5 g/mL at 25 °C (lit.)

SMILES字符串

N(C)(C)c1cc(c(cc1)C(N)CC)C

InChI

1S/C12H20N2/c1-5-12(13)11-7-6-10(14(3)4)8-9(11)2/h6-8,12H,5,13H2,1-4H3

InChI key

RRHXDYJWVYFMKV-UHFFFAOYSA-N

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一般描述

羟丙基纤维素(HPC)是一种非离子衍生物纤维素。它是一种热敏、可生物降解的聚合物,具有较低的临界溶液温度。

应用

羟丙基纤维素可 用于制备用于药物递送系统的复合纳米球。 甲基丙烯酸羟丙酯/羟基纤维素接枝共聚物 可用作控释片的基质。 它也可以用作电解质添加剂,制备用于染料敏化太阳能电池的凝胶聚合物电解质。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

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Hyemin Choi et al.
Journal of pharmaceutical sciences, 101(8), 2941-2951 (2012-05-26)
Living organisms secrete minerals composed of peptides and proteins, resulting in "mesocrystals" of three-dimensional-assembled composite structures. Recently, this biomimetic polymer-directed crystallization technique has been widely applied to inorganic materials, although it has seldom been used with drugs. In this study
Ranjit M Dhenge et al.
International journal of pharmaceutics, 438(1-2), 20-32 (2012-09-11)
The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of
Weibin Deng et al.
Drug development and industrial pharmacy, 39(2), 290-298 (2012-04-25)
The objective of this study was to improve the dissolution rate and to enhance the stability of a poorly water-soluble and low glass-trasition temperature (T(g)) model drug, fenofibrate, in low molecular weight grades of hydroxypropylcellulose matrices produced by hot-melt extrusion
Satomi Onoue et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(5), 492-499 (2012-04-14)
The present study was undertaken to develop a solid self-emulsifying drug delivery system of coenzyme Q(10) (CoQ(10)/s-SEDDS) with high photostability and oral bioavailability. The CoQ(10)/s-SEDDS was prepared by spray-drying an emulsion preconcentrate containing CoQ(10), medium-chain triglyceride, sucrose ester of fatty
Alexandre Monteiro et al.
Drug development and industrial pharmacy, 39(2), 266-283 (2012-04-17)
Nanoparticles of BCS Class II drugs are produced in wet stirred media mills operating in batch or recirculation mode with the goal of resolving the poor water-solubility issue. Scant information is available regarding the continuous production of drug nanoparticles via

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