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Merck
CN

191884

羟丙基纤维素

average Mw ~100,000, powder, 20 mesh particle size (99% through)

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化学文摘社编号:
UNSPSC Code:
12162002
NACRES:
NA.23
MDL number:
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SMILES string

N(C)(C)c1cc(c(cc1)C(N)CC)C

InChI

1S/C12H20N2/c1-5-12(13)11-7-6-10(14(3)4)8-9(11)2/h6-8,12H,5,13H2,1-4H3

InChI key

RRHXDYJWVYFMKV-UHFFFAOYSA-N

description

biological oxygen demand (BOD) 14,000 ppm

form

powder

autoignition temp.

752 °F

mol wt

average Mw ~100,000

impurities

<5 wt. %

particle size

20 mesh (99% through)

pH

5.0-8.5

interfacial tension mineral oil

12.5 dyn/cm, 0.1 wt. % in H2O (vs. mineral oil)

viscosity

65-175 cP, 5 wt. % in H2O(25 °C, Brookfield, spindle #1) (30 rpm)(lit.)

solubility

polar organic solvents: soluble

density

0.5 g/mL at 25 °C (lit.)

Quality Level

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General description

羟丙基 纤维素(HPC)是由环氧丙烷和碱性纤维素 在高温高压下反应制备的中性多糖。它可溶 于水和许多极性有机溶剂。HPC 被广泛用作食品 添加剂和药物递送系统。

Application

羟丙基纤维素可 用于以下应用:
  • HPC 可溶 于有机溶剂,这使其适合于 制备用于电化学设备的聚合物凝胶电解质。HPC 的网络形成能力可以改善凝胶电解质的机械和电 学性能。
  • 电纺 羟丙基纤维素纳米纤维可用于开发 各种疏水性药物的药物递送系统。
  • 羟丙基纤维素与碳酸钠等泡腾剂相结合,可作为粘合剂和功能材料制备用于控制氧氟沙星释放的漂浮片。

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Xiaole Qi et al.
International journal of pharmaceutics, 489(1-2), 210-217 (2015-05-10)
To prolong the residence time of dosage forms within gastrointestinal trace until all drug released at desired rate was one of the real challenges for oral controlled-release drug delivery system. Herein, we developed a fine floating tablet via compression coating
Jeremiah F Kelleher et al.
AAPS PharmSciTech, 21(1), 23-23 (2019-12-14)
The development of oral solid dosage forms, such as tablets that contain a high dose of drug(s), requires polymers and other additives to be incorporated at low levels as possible, to keep the final tablet weight low, and, correspondingly, the
Ranjit M Dhenge et al.
International journal of pharmaceutics, 438(1-2), 20-32 (2012-09-11)
The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of
Daniela M Correia et al.
Materials (Basel, Switzerland), 13(10) (2020-05-21)
This study reports a versatile method for the development of cellulose nanocrystals (CNCs) and water-soluble cellulose derivatives (methyl cellulose (MC), hydroxypropyl cellulose (HPC), and sodium carboxymethyl cellulose (NaCMC)) films comprising the ionic liquid (IL) 2-hydroxy-ethyl-trimethylammonium dihydrogen phosphate ([Ch][DHP]) for actuator
Maya Fujiwara et al.
Chemical & pharmaceutical bulletin, 60(11), 1380-1386 (2012-11-06)
We evaluated models for predicting spray mist diameter suitable for scaling-up the fluidized bed granulation process. By precise selection of experimental conditions, we were able to identify a suitable prediction model that considers changes in binder solution, nozzle dimension, and

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