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Merck
CN

191140

Sigma-Aldrich

7-氨基头孢烷酸

98%

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别名:
7-ACA
经验公式(希尔记法):
C10H12N2O5S
CAS号:
分子量:
272.28
Beilstein:
622637
EC 号:
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.22

质量水平

检测方案

98%

形式

powder

旋光性

[α]19/D +90°, c = 0.5 in KH2PO4/trace NaOH

反应适用性

reaction type: solution phase peptide synthesis

mp

>300 °C (lit.)

抗生素抗菌谱

Gram-positive bacteria

应用

peptide synthesis

作用机制

cell wall synthesis | interferes

储存温度

2-8°C

SMILES字符串

[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2N)C(O)=O

InChI

1S/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)/t6-,9-/m1/s1

InChI key

HSHGZXNAXBPPDL-HZGVNTEJSA-N

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一般描述

化学结构:β-内酰胺

应用

7-氨基头孢烷酸(7-ACA)可用作制备以下物质的原料:
  • 在三乙胺存在的情况下与 S-苯并噻唑-2-基(2-氨基-4-噻唑基)(甲氧基亚氨基)硫代乙酸酯 (MAEM)反应合成的头孢噻肟 。
  • 通过头孢噻肟中间体合成的第三代抗生素头孢泊肟酯。
  • 作为β-内酰胺酶潜在抑制剂的3′-取代头孢菌素钠砜衍生物。

细菌(金黄色葡萄球菌)β-内酰胺酶的有效抑制剂。

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Resp. Sens. 1 - Skin Sens. 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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d-amino acid oxidase (DAAO, EC 1.4.3.3) is used in many biotechnological processes. The main industrial application of DAAO is biocatalytic production of 7-aminocephalosporanic acid from cephalosporin C with a two enzymes system. DAAO from the yeast Trigonopsis variabilis (TvDAAO) shows
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In this study, a lab-scale multiple draft tubes airlift loop membrane bioreactor (Mt-ALMBR) was used for treating acidic 7-amino cephalosporanic acid (7-ACA) wastewater under different pHs (3.54-6.20) and hydraulic retention time (HRT) (48 h, 36 h, 24 h and 16 h). During about 200 days
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