推荐产品
质量水平
方案
97%
表单
solid
mp
98-100 °C (lit.)
溶解性
methanol: soluble 50 mg/mL, clear, colorless
官能团
carboxylic acid
phenyl
SMILES字符串
OC(=O)C(C1CCCC1)c2ccccc2
InChI
1S/C13H16O2/c14-13(15)12(11-8-4-5-9-11)10-6-2-1-3-7-10/h1-3,6-7,11-12H,4-5,8-9H2,(H,14,15)
InChI key
BCJIDGDYYYBNNB-UHFFFAOYSA-N
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应用
Cyclopentylphenylacetic acid was used in the synthesis of:
- 1-cyclopentyl-l-phenyl-2-(p-alkoxyphenyl)ethylenes
- soft ester analogs of anticholinergics
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
F Huang et al.
Die Pharmazie, 57(2), 115-121 (2002-03-07)
Four new soft anticholinergic agents based on tropyl alpha-phenylcyclopentylacetate, 15a, 15b, 18a, and 18b, were designed and synthesized. Receptor binding studies on the cloned human muscarinic receptors indicated that the new soft anticholinergic agents possessed moderate potency as pKi ranged
B Liebmann et al.
Arzneimittel-Forschung, 42(11), 1354-1358 (1992-11-01)
Ester hydrolysis represents an important biotransformation pathway for various parasympatholytic agents. Cleavage of the ciclotropium ester bond results in the formation of alpha-phenylciclopentylacetic acid (PCA). The relevance of this metabolic route for ciclotropium bromide (HIT-PCE, CAS 85166-20-7) including its stereochemical
N Bodor et al.
Journal of medicinal chemistry, 23(5), 474-480 (1980-05-01)
A new class of antimuscarinic drugs was designed and synthesized. The compounds are "soft" quaternary ammonium esters in which there is only one carbon atom separating the ester oxygen and the quaternary head. The compounds are potent anticholinergics when derived
664. Chemical constitution and sex-hormonal activity: the synthesis of of some 1-cyclopentyl-and 1-cyclohexyl-1: 2-diarylethylenes.
Hey DH and Musgrave OC.
Journal of the Chemical Society, 3156-3164 (1949)
Radoslaw Laufer et al.
Bioorganic & medicinal chemistry, 22(17), 4968-4997 (2014-07-22)
TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and acetamido moieties at
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