189782
4-氧代-4H-1-苯并吡喃-2-羧酸
97%
别名:
4-氧代-4H-1-苯并吡喃-2-羧酸, 色烯卡, 色酮-2-羧酸
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关于此项目
经验公式（希尔记法）:
C10H6O4
化学文摘社编号:
分子量:
190.15
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
225-583-0
MDL number:
产品名称
4-氧代-4H-1-苯并吡喃-2-羧酸, 97%
InChI key
RVMGXWBCQGAWBR-UHFFFAOYSA-N
InChI
1S/C10H6O4/c11-7-5-9(10(12)13)14-8-4-2-1-3-6(7)8/h1-5H,(H,12,13)
SMILES string
OC(=O)C1=CC(=O)c2ccccc2O1
assay
97%
form
powder
mp
260 °C (dec.) (lit.)
solubility
alcohol: soluble
ammonium hydroxide: soluble
water: very slightly soluble
functional group
carboxylic acid
ketone
Quality Level
Gene Information
human ... PTPN1(5770)
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General description
Nasal absorption of 4-oxo-4H-1-benzopyran-2-carboxylic acid has been investigated in the male Wistar rat.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
J Swarbrick et al.
Journal of pharmaceutical sciences, 73(10), 1352-1355 (1984-10-01)
The aim of this study was to establish whether ionized as well as un-ionized forms of certain 4-oxo-4H-1-benzopyran-2-carboxylic acids (chromone-2-carboxylic acids) with pKa values less than 2 permeated through excised human skin and, if so, to determine the permeability coefficients
Stefano Alcaro et al.
Bioorganic & medicinal chemistry letters, 20(9), 2709-2712 (2010-04-13)
Chromone carboxylic acids were evaluated as human monoamine oxidase A and B (hMAO-A and hMAO-B) inhibitors. The biological data indicated that only chromone-3-carboxylic acid is a potent hMAO-B inhibitor, with a high degree of selectivity for hMAO-B compared to hMAO-A.
Chromone-2-carboxylic acids: roles of acidity and lipophilicity in drug disposition.
D A Smith et al.
Drug metabolism reviews, 16(4), 365-388 (1985-01-01)
A N Fisher et al.
The Journal of pharmacy and pharmacology, 39(5), 357-362 (1987-05-01)
The nasal absorption of a range of water-soluble compounds with different molecular weights, 4-oxo-4H-1-benzopyran-2-carboxylic acid (mol. wt 190), p-aminohippuric acid (mol. wt 194), inulin (mol. wt 5200) and dextran (mol. wt 70,000), has been investigated in the male Wistar rat.
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