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Merck
CN

184047

Sigma-Aldrich

(S)-(+)-亮氨醇

96%

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别名:
(S)-2-氨基-4-甲基-1-戊醇, 2-氨基-4-甲基-1-戊醇, L-亮氨醇
线性分子式:
(CH3)2CHCH2CH(NH2)CH2OH
CAS号:
分子量:
117.19
Beilstein:
1719240
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:

检测方案

96%

旋光性

[α]20/D +4°, c = 9 in ethanol

光学纯度

ee: 99% (GLC)

反应适用性

reaction type: solution phase peptide synthesis

折射率

n20/D 1.4511 (lit.)

bp

198-200 °C/768 mmHg (lit.)

密度

0.917 g/mL at 25 °C (lit.)

应用

peptide synthesis

SMILES字符串

CC(C)C[C@H](N)CO

InChI

1S/C6H15NO/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m0/s1

InChI key

VPSSPAXIFBTOHY-LURJTMIESA-N

应用

合成氨肽酶 N 和磷脂酶 A2 抑制剂的原料。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

195.8 °F

闪点(°C)

91 °C

个人防护装备

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

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C Bennion et al.
Journal of medicinal chemistry, 35(16), 2939-2951 (1992-08-07)
A series of substrate analogue inhibitors of pancreatic phospholipase A2 has been designed and synthesized. The compounds were tested in a novel dual-screening system based on parallel assays with monomeric and micellar substrates. Intermolecular nuclear Overhauser effects between vinylic protons
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American journal of physiology. Heart and circulatory physiology, 282(3), H1135-H1148 (2002-02-09)
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P T Pham et al.
Journal of cellular biochemistry, 79(3), 427-441 (2000-09-06)
Enhanced phosphorylation of the ribosomal protein s6 kinase, p70(s6k), and the translational repressor, 4E-BP1, are associated with either insulin-induced or amino acid-induced protein synthesis. Hyperphosphorylation of p70(s6k) and 4E-BP1 in response to insulin or amino acids is mediated through the
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Fungal non-ribosomal peptide synthetase (NRPS) clusters are spread across the chromosomes, where several modifying enzyme-encoding genes typically flank one NRPS. However, a recent study showed that the octapeptide fusaoctaxin A is tandemly synthesized by two NRPSs in Fusarium graminearum. Here
Chiral derivatives of xanthones and benzophenones: Synthesis, enantioseparation, molecular docking, and tumor cell growth inhibition studies.
Ye' Zaw Phyo et al.
Chirality, 33(4), 153-166 (2021-01-16)

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