180246
2-萘甲酸
98%
别名:
2-萘酸
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线性分子式:
C10H7CO2H
化学文摘社编号:
分子量:
172.18
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-217-8
Beilstein/REAXYS Number:
972039
MDL number:
Assay:
98%
Form:
powder
产品名称
2-萘甲酸, 98%
InChI key
UOBYKYZJUGYBDK-UHFFFAOYSA-N
InChI
1S/C11H8O2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H,12,13)
SMILES string
OC(=O)c1ccc2ccccc2c1
assay
98%
form
powder
mp
185-187 °C (lit.)
solubility
alcohol: soluble
diethyl ether: soluble
hot water: slightly soluble
functional group
carboxylic acid
Quality Level
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General description
2-萘甲酸（NPA）是一种非竞争性N-甲基-D-天冬氨酸（NMDA）受体抑制剂。已经研究了2-萘甲酸的荧光光谱和电子吸收。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
An electronic spectral study of the influence of thermal and electronic processes on the determination of the excited singlet-state dissociation constants of 1-and 2-naphthoic acid.
Kovi PJ and Schulman SG.
Analytica Chimica Acta, 63(1), 39-52 (1973)
D P McNamara et al.
Journal of pharmaceutical sciences, 75(9), 858-868 (1986-09-01)
A mass transfer model was developed to describe the dissolution and reaction of acidic and basic compounds from a rotating disk in unbuffered water. Dissolution of two carboxylic acids, 2-naphthoic acid (1) and naproxen [(+)-6-methoxy-alpha-methyl-2-naphthaleneacetic acid, 2], and the free
K G Mooney et al.
Journal of pharmaceutical sciences, 70(12), 1358-1365 (1981-12-01)
This study investigated the possible effects of simultaneous, noninstantaneous, reversible chemical ionization of carbon acids on the dissolution of a typical pharmaceutical carbon acid, phenylbutazone, and its deutero analog. The dissolution rate versus pH profile for phenylbutazone was consistent with
Han Yu et al.
Molecular pharmacology, 84(4), 541-550 (2013-07-23)
N-Methyl-D-aspartate (NMDA) receptors mediate excitatory synaptic transmission in the central nervous system and play important roles in synaptic development and plasticity, but also mediate glutamate neurotoxicity. Recently, 2-naphthoic acid (NPA) and its derivatives have been identified as allosteric, noncompetitive NMDA
Blaise Mathias Costa et al.
Neuropharmacology, 62(4), 1730-1736 (2011-12-14)
Over-activation of N-methyl-d-aspartate (NMDA) receptors is critically involved in many neurological conditions, thus there has been considerable interest in developing NMDA receptor antagonists. We have recently identified a series of naphthoic and phenanthroic acid compounds that allosterically modulate NMDA receptors
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