InChI key
OSILBMSORKFRTB-UHFFFAOYSA-N
InChI
1S/C9H8N2/c10-9-8-4-2-1-3-7(8)5-6-11-9/h1-6H,(H2,10,11)
SMILES string
Nc1nccc2ccccc12
assay
99%
mp
122-124 °C (lit.)
Application
1-Aminoisoquinoline was used in the synthesis of pyrimidoisoquinolinone.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Danqing Zheng et al.
Organic & biomolecular chemistry, 9(13), 4763-4765 (2011-05-28)
2-Alkynylbenzaldoxime reacts with amine catalyzed by silver triflate under mild conditions, leading to 1-aminoisoquinolines in good yield. This reaction proceeds efficiently with good functional group tolerance.
Scott P Brown et al.
Journal of medicinal chemistry, 52(10), 3159-3165 (2009-04-24)
We apply a high-throughput formulation of the molecular mechanics with Poisson-Boltzmann surface area (htMM-PBSA) to estimate relative binding potencies on a set of 308 small-molecule ligands in complex with the proteins urokinase, PTP-1B, and Chk-1. We observe statistically significant correlation
J B Rewinkel et al.
Bioorganic & medicinal chemistry letters, 9(5), 685-690 (1999-04-14)
Replacement of the highly basic benzamidine moiety of NAPAP by the moderately basic 1-aminoisoquinoline moiety resulted in thrombin inhibitors with improved selectivity towards trypsin and enhanced Caco-2 cell permeability.
Hervé Bibas et al.
The Journal of organic chemistry, 67(8), 2619-2631 (2002-04-13)
The synthesis, spectroscopic properties, and chemical reactions of the stable (neopentylimino)-, (mesitylimino)-, and (o-tert-butylphenylimino)propadienones (6) are reported. Nucleophilic addition of amines affords the malonic amidoamidines 7 and 8. 3,5-Dimethylpyrazole reacts analogously to form 9b. Addition of 1,2-dimethylhydrazine produces pyrazolinones 10-12.
[A practical method for the synthesis of 1-aminoisoquinoline].
S Giorgi-Renault et al.
Annales pharmaceutiques francaises, 41(6), 555-557 (1983-01-01)
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