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线性分子式:
CF3C6H4OH
化学文摘社编号:
分子量:
162.11
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-945-7
Beilstein/REAXYS Number:
1637019
MDL number:
Assay:
97%
Form:
liquid
InChI key
BAYGVMXZJBFEMB-UHFFFAOYSA-N
InChI
1S/C7H5F3O/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4,11H
SMILES string
Oc1ccc(cc1)C(F)(F)F
assay
97%
form
liquid
mp
45-47 °C (lit.)
functional group
fluoro
storage temp.
2-8°C
General description
4-(三氟甲基)苯酚分子,与 H61T(HIS-61→苏氨酸)突变体的活性位点结合,密度较强。
4-(三氟甲基)苯酚又称p-三氟甲基苯酚,用于合成聚合物和单体。
4-(三氟甲基)苯酚又称p-三氟甲基苯酚,用于合成聚合物和单体。
Application
4-(三氟甲基)苯酚(4- hydroxybenzotrifluoride)被用于二芳基醚的合成。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Sol. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
4.1B - Flammable solid hazardous materials
wgk
WGK 3
flash_point_f
183.2 °F - closed cup
flash_point_c
84 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
M W Fraaije et al.
The Journal of biological chemistry, 275(49), 38654-38658 (2000-09-14)
Vanillyl-alcohol oxidase (VAO) is member of a newly recognized flavoprotein family of structurally related oxidoreductases. The enzyme contains a covalently linked FAD cofactor. To study the mechanism of flavinylation we have created a design point mutation (His-61 --> Thr). In
B van de Wier et al.
Chemico-biological interactions, 242, 139-144 (2015-10-03)
Cytochrome P450 2E1 (CYP2E1) expression and activity in the liver is associated with the degree of liver damage in patients with alcoholic steatohepatitis (ASH) as well as non-alcoholic steatohepatitis (NASH). CYP2E1 is known to generate reactive oxygen species, which leads
Przemysław Drzewicz et al.
Environmental technology, 40(25), 3265-3275 (2018-05-15)
A large amount of pharmaceuticals are flushed to environment via sewage system. The compounds are persistent in environment and are very difficult to remove in drinking water treatment processes. Degradation of fluoxetine (FLU) and fluvoxamine (FLX) by ferrate(VI) were investigated.
Lisa Bauer et al.
ACS infectious diseases, 5(9), 1609-1623 (2019-07-16)
Enteroviruses (family Picornaviridae) comprise a large group of human pathogens against which no licensed antiviral therapy exists. Drug-repurposing screens uncovered the FDA-approved drug fluoxetine as a replication inhibitor of enterovirus B and D species. Fluoxetine likely targets the nonstructural viral
L J Urichuk et al.
Journal of chromatography. B, Biomedical sciences and applications, 698(1-2), 103-109 (1997-11-21)
An electron-capture gas chromatographic procedure was developed for the analysis of p-trifluoromethylphenol, an O-dealkylated metabolite of fluoxetine, in biological samples. A basic extraction of the biological sample was employed, followed by derivatization with pentafluorobenzenesulfonyl chloride. The internal standard, 2,4-dichlorophenol, was
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