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质量水平
方案
97%
表单
liquid
折射率
n20/D 1.4531 (lit.)
沸点
151-154 °C (lit.)
密度
0.855 g/mL at 25 °C (lit.)
SMILES字符串
CC1CCC(N)CC1
InChI
1S/C7H15N/c1-6-2-4-7(8)5-3-6/h6-7H,2-5,8H2,1H3
InChI key
KSMVBYPXNKCPAJ-UHFFFAOYSA-N
一般描述
Trans-4-methylcyclohexylamine is a spermidine synthase inhibitor.
警示用语:
Danger
危险声明
危险分类
Flam. Liq. 3 - Skin Corr. 1B
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
80.6 °F - closed cup
闪点(°C)
27 °C - closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
Cancer prevention research (Philadelphia, Pa.), 3(2), 140-147 (2010-01-28)
The oncogenic transcription factor c-Myc (Myc) is frequently overexpressed in human cancers. Myc is known to induce or repress a large set of genes involved in cell growth and proliferation, explaining the selection for mutations in cancer that deregulate Myc
Biological & pharmaceutical bulletin, 28(4), 569-573 (2005-04-02)
In rat tissues, a decrease in spermidine, accompanied by an increase in spermine was induced by the oral administration (once daily for either 1 week or 1 month) of trans-4-methylcyclohexylamine (4MCHA), a spermidine synthase inhibitor. This is similar to the
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 845(1), 80-83 (2006-08-26)
An assay for spermidine synthase (SPDS) activity in rat liver has been developed using micellar electrokinetic chromatography (MEKC) with laser-induced fluorescence (LIF) detection to enable the discovery of SPDS inhibitors. The assay was established by estimating the amount of spermidine
Trans-4-methylcyclohexylamine, a potent new inhibitor of spermidine synthase.
Chemical & pharmaceutical bulletin, 36(8), 3220-3222 (1988-08-01)
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 126(8), 529-542 (2006-08-02)
This review describes my work in the field of polyamine research for the last 35 years. My research started with developing the improved synthesis of decarboxylated S-adenosylmethionine and then moved to the purification of spermidine synthase from rat prostate. I
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