176974
2,4-二羟基吡啶
97%
别名:
2,4-吡啶二醇, 3-Deazauracil, 4-羟基-2-吡啶酮
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关于此项目
经验公式（希尔记法）:
C5H5NO2
化学文摘社编号:
分子量:
111.10
EC Number:
210-924-8
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
108533
MDL number:
Assay:
97%
Form:
solid
mp
272-276 °C (lit.)
InChI key
ZEZJPIDPVXJEME-UHFFFAOYSA-N
InChI
1S/C5H5NO2/c7-4-1-2-6-5(8)3-4/h1-3H,(H2,6,7,8)
SMILES string
Oc1ccnc(O)c1
assay
97%
form
solid
General description
2,4-Dihydroxypyridine (3-deazauracil) is a potent inhibitor of dihydrouracil dehydrogenase.
Application
2,4-Dihydroxypyridine (3-deazauracil) was used in the synthesis of diazaphenoxathiin skeleton.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
M Kaneko et al.
Nucleic acids symposium series, (12)(12), 13-16 (1983-01-01)
New method for a synthesis of diazaphenoxathiin skeleton from 3-deazauracil derivatives is reported. It became possible to convert 3-deazauridine to 3-deazacytidine via an excellent intermediate "diazaphenoxathiin sulfoxide derivative".
M T Cocco et al.
European journal of medicinal chemistry, 35(5), 545-552 (2000-07-12)
4-hydroxy-2-pyridone derivatives 2 were prepared by reaction of 3-amino-3-dialkylaminopropenoates with bis(2,4, 6-trichlorophenyl)malonate. These compounds were further reacted with a set of aldehydes to give bis(pyridyl)methanes 3 and 4. The newly synthesized compounds 2, 3 and 4 were evaluated in vitro
F N Naguib et al.
Biochemical pharmacology, 38(9), 1471-1480 (1989-05-01)
One hundred and five nucleobase analogues were screened as inhibitors of dihydrouracil dehydrogenase (DHUDase, EC 1.3.1.2) from mouse liver. 5-Benzyloxybenzyluracil, 1-deazauracil (2,6-pyridinediol), 3-deazauracil (2,4-pyridinediol), 5-benzyluracil, 5-nitrobarbituric acid and 5,6-dioxyuracil (alloxan) were identified as potent inhibitors of this activity, with apparent
J Molgó et al.
Journal de pharmacologie, 16 Suppl 2, 109-144 (1985-01-01)
In this review the effects of aminopyridines and chemically related compounds are documented in an attempt to analyse the mechanism underlying their presynaptic actions at the vertebrate neuromuscular junction. Aminopyridines and related compounds are of particular interest because they greatly
K T Lin et al.
Therapeutic drug monitoring, 5(4), 491-496 (1983-01-01)
A rapid and simple procedure for liquid chromatographic analysis of plasma 3-deazauridine (3-DU), an antineoplastic agent, was developed. The plasma was extracted with methanolic silver acetate to remove interfering ultraviolet-absorbing materials and the 3-DU partially purified on a small anion
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