162957
6-羟基多巴胺 氢溴酸盐
95% (HPLC), powder, neurotoxin
别名:
2-（2，4，5-三羟基苯基）乙胺 氢溴酸盐, 2，4，5-三羟基苯乙胺 氢溴酸盐, 2，5-二羟基酪胺 氢溴酸盐, 6 -羟基多巴胺
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关于此项目
线性分子式:
(HO)3C6H2CH2CH2NH2 · HBr
化学文摘社编号:
分子量:
250.09
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
211-247-0
MDL number:
Beilstein/REAXYS Number:
3713280
Application
6-羟基多巴胺合溴化氢可用于：
- 诱导小鼠模型中的帕金森病（PD）以研究tubastatin A （TBA）对SH-SY5Y细胞中核苷酸结合寡聚化结构域和富亮氨酸重复Pyrin 3序列结构域（NLRP3） 以及细胞损伤的作用。
- 诱导交感神经的药理学消融以研究肝交感神经活性（SNA）对食源性肥胖小鼠中肝脂肪变性的作用
- 诱导中脑细胞中的氧化应激以研究其对腹侧中脑的神经元细胞中p75NTR 信号传递的作用。
Biochem/physiol Actions
6-羟基多巴胺合溴化氢（6-OHDA）是一种神经毒素，可诱导氧化损伤并破坏含儿茶酚胺或交感神经末梢。它常用于诱发实验模型中的帕金森′病。6-OHDA可通过产生活性氧物质，引发细胞应激和细胞死亡而发挥细胞毒性。
General description
溶液应新鲜制备，并且应避光。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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C C Real et al.
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Physical exercise is known to produce beneficial effects to the nervous system. In most cases, brain-derived neurotrophic factor (BDNF) is involved in such effects. However, little is known on the role of BDNF in exercise-related effects on Parkinson's disease (PD).
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