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方案
98%
表单
solid
mp
>300 °C (lit.)
溶解性
soluble 50 mg/mL, clear, colorless to faintly yellow (DMF:MeOH(2:1))
官能团
phenyl
SMILES字符串
Oc1ccc(cc1)C2(NC(=O)NC2=O)c3ccccc3
InChI
1S/C15H12N2O3/c18-12-8-6-11(7-9-12)15(10-4-2-1-3-5-10)13(19)16-14(20)17-15/h1-9,18H,(H2,16,17,19,20)
InChI key
XEEDURHPFVXALT-UHFFFAOYSA-N
一般描述
5-(4-Hydroxyphenyl)-5-phenylhydantoin is the major metabolite of phenytoin.
应用
5-(4-Hydroxyphenyl)-5-phenylhydantoin was used in enantiomeric separation of chiral pharmaceuticals using a teicoplanin chiral stationary phase by aqueous and non-aqueous packed capillary electrochromatography. It was used as internal standard in determination of phenylbutazone and its metabolite oxyphenbutazone in human plasma by GLC.
Reactant for activation of hydroxylated metabolites of carbamazepine and phenytoin
Used in studies investigating
Transport across the human placenta barrier
Effects on cellular glucose transport
Used in studies investigating
Transport across the human placenta barrier
Effects on cellular glucose transport
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
A Takahashi et al.
Japanese journal of pharmacology, 82(1), 82-84 (2000-06-30)
The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This
Vikas Kumar et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(12), 1966-1975 (2006-09-12)
Drug-drug interactions may cause serious adverse events in the clinical setting, and the cytochromes P450 are the enzyme system most often implicated in these interactions. Cytochrome P450 2C is the second most abundant subfamily of cytochrome P450 enzymes and is
Joo-Ho Park et al.
Biotechnology and bioengineering, 78(7), 779-793 (2002-05-10)
We developed a kinetic model that describes a heterogeneous reaction system for the production of D-p-hydroxyphenylglycine from D,L-p-hydroxyphenyl-hydantoin using D-hydantoinase of Bacillus stearothermophilus SD1 and N-carbamoylase of Agrobacterium tumefaciens NRRL B11291. As a biocatalyst, whole cells with separately or co-expressed
Miki Nakajima et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(11), 1250-1256 (2002-10-19)
In humans, orally administered phenytoin, 5,5-diphenylhydantoin, is mainly excreted as 5-(4'-hydroxyphenyl)-5-phenylhydantoin (4'-HPPH) O-glucuronide. Phenytoin is oxidized to 4'-HPPH by CYP2C9 and to a minor extent by CYP2C19, and then 4'-HPPH is metabolized to 4'-HPPH O-glucuronide by UDP-glucuronosyltransferase (UGT). In the
Phenytoin overview--metabolite interference in some immunoassays could be clinically important.
William L Roberts et al.
Archives of pathology & laboratory medicine, 128(7), 734-734 (2004-07-02)
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