146625
二磺酸 Bathocuproinedisulfonic acid 二钠盐 水合物
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经验公式（希尔记法）:
C26H18N2Na2O6S2 · xH2O
化学文摘社编号:
分子量:
564.54 (anhydrous basis)
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Form:
powder
InChI
1S/C26H20N2O6S2.2Na.H2O/c1-15-25(35(29,30)31)21(17-9-5-3-6-10-17)19-13-14-20-22(18-11-7-4-8-12-18)26(36(32,33)34)16(2)28-24(20)23(19)27-15;;;/h3-14H,1-2H3,(H,29,30,31)(H,32,33,34);;;1H2/q;2*+1;/p-2
SMILES string
O.[Na+].[Na+].Cc1nc2c(ccc3c(-c4ccccc4)c(c(C)nc23)S([O-])(=O)=O)c(-c5ccccc5)c1S([O-])(=O)=O
InChI key
ZAGWMJUGRCMNGX-UHFFFAOYSA-L
form
powder
mp
300 °C (lit.)
functional group
phenyl, sulfonic acid
General description
浴铜灵二磺酸二钠盐 (BCDS) 是一种稳定的 Cu + 螯合剂，BCDS-Cu + 抑制 HIV-1 野生型蛋白酶以及缺乏半胱氨酸的突变型 HIV-1 蛋白酶 。是一种细胞外铜螯合剂 。
Application
在电子自旋共振自旋捕集技术中，以浴铜灵二磺酸二钠水合盐为螯合剂，研究急性甲酸钠中毒大鼠自由基的产生 。将其作为测定 Cu 和 Cu 蛋白复合物的试剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A E Dikalova et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(24), 13549-13553 (2001-11-22)
Electron spin resonance spectroscopy has been used to study free radical generation in rats with acute sodium formate poisoning. The in vivo spin-trapping technique was used with alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone (POBN), which reacts with free radical metabolites to form radical adducts, which
M Matsushita et al.
Clinica chimica acta; international journal of clinical chemistry, 216(1-2), 103-111 (1993-07-16)
A method of protein determination has been developed which combines the biuret reaction and the copper(I)-bathocuproine chelate reaction. Protein in the specimen forms a Cu(2+)-protein chelate complex (biuret reaction) during the first step. Excess Cu2+ is reduced to Cu+ by
Suzie Kang et al.
International journal of molecular sciences, 21(20) (2020-10-22)
Copper is an essential metal ion that performs many physiological functions in living organisms. Deletion of Afmac1, which is a copper-responsive transcriptional activator in A. fumigatus, results in a growth defect on aspergillus minimal medium (AMM). Interestingly, we found that
The Geomagnetic Field Is a Contributing Factor for an Efficient Iron Uptake in Arabidopsis thaliana.
Monirul Islam et al.
Frontiers in plant science, 11, 325-325 (2020-05-07)
The Earth's magnetic field, defined as the geomagnetic field (GMF), is an unavoidable environmental factor for all living organisms. Variation in the GMF intensity was found to affect the content of some nutrients and their associated channels and transporters in
D A Davis et al.
Archives of biochemistry and biophysics, 322(1), 127-134 (1995-09-10)
The protease encoded by the human immunodeficiency virus-1 (HIV-1) is essential for processing viral polyproteins which contain the enzymes and structural proteins required for the infectious virus. It was previously found that cupric chloride, in the presence of dithiothreitol or
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