146358
N-乙基-2-吡咯烷酮
98%
别名:
NEP
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关于此项目
经验公式（希尔记法）:
C6H11NO
化学文摘社编号:
分子量:
113.16
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
220-250-6
Beilstein/REAXYS Number:
107971
MDL number:
Assay:
98%
Form:
liquid
InChI key
ZFPGARUNNKGOBB-UHFFFAOYSA-N
InChI
1S/C6H11NO/c1-2-7-5-3-4-6(7)8/h2-5H2,1H3
SMILES string
CCN1CCCC1=O
assay
98%
form
liquid
refractive index
n20/D 1.465 (lit.)
bp
97 °C/20 mmHg (lit.)
density
0.992 g/mL at 25 °C (lit.)
Quality Level
General description
1-乙基-2-吡咯烷酮是一种透皮吸收增强化合物，其对角质层脂质的多层脂质体的作用机制已被研究。
Application
1-乙基-2-吡咯烷酮用于通过光固化而修饰椰壳纤维（来源于椰子（ Cocos nucifera））。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
195.8 °F - Pensky-Martens closed cup
flash_point_c
91 °C - Pensky-Martens closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Effect of penetration enhancers (pyrrolidone derivatives) on multilamellar liposomes of stratum corneum lipid: a study by UV spectroscopy and differential scanning calorimetry.
Kim C-K, et al.
International Journal of Pharmaceutics, 95(1), 43-50 (1993)
Takeshi Katsuda et al.
Scientific reports, 3, 1197-1197 (2013-02-05)
Alzheimer's disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ) in the brain because of an imbalance between Aβ production and clearance. Neprilysin (NEP) is the most important Aβ-degrading enzyme in the brain. Thus, researchers have explored virus-mediated
Ajeet Kaushik et al.
Scientific reports, 7, 45663-45663 (2017-04-05)
In this research, we demonstrate cell uptake of magneto-electric nanoparticles (MENPs) through nanoelectroporation (NEP) using alternating current (ac)-magnetic field stimulation. Uptake of MENPs was confirmed using focused-ion-beam assisted transmission electron microscopy (FIB-TEM) and validated by a numerical simulation model. The
Xiaolei Zhu et al.
Aging cell, 16(5), 1073-1082 (2017-08-05)
The accumulation and deposition of beta-amyloid (Aβ) is a key neuropathological hallmark of Alzheimer's disease (AD). Histone deacetylases (HDACs) are promising therapeutic targets for the treatment of AD, while the specific HDAC isoforms associated with cognitive improvement are poorly understood.
Francisco M Pinto et al.
Reproductive biology and endocrinology : RB&E, 8, 104-104 (2010-08-28)
We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa. Freshly ejaculated semen was collected from forty-eight normozoospermic human donors. We analyzed the expression of substance P, neurokinin A, neurokinin
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