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Merck
CN

145378

Sigma-Aldrich

4,6-二氯嘧啶

97%

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经验公式(希尔记法):
C4H2Cl2N2
CAS号:
分子量:
148.98
Beilstein:
111195
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

质量水平

检测方案

97%

形式

solid

bp

176 °C (lit.)

mp

65-67 °C (lit.)

溶解性

95% ethanol: soluble 50 mg/mL, clear to very slightly hazy, colorless to yellow

SMILES字符串

Clc1cc(Cl)ncn1

InChI

1S/C4H2Cl2N2/c5-3-1-4(6)8-2-7-3/h1-2H

InChI key

XJPZKYIHCLDXST-UHFFFAOYSA-N

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一般描述

4,6-二氯嘧啶的循环伏安图显示三个阴极波,由碳氯键的连续断裂以及嘧啶的还原产生

应用

N -取代氮杂杯嘧啶的合成中使用了 [4,6-二氯嘧啶 。它被用作通过串联胺化和 Suzuki-Miyaura 交叉偶联合成双取代嘧啶的起始试剂 。它也用于涉及联芳交叉耦合的联芳嘧啶合成。

象形图

Corrosion

警示用语:

Danger

危险声明

危险分类

Skin Corr. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Li-Xia Wang et al.
The Journal of organic chemistry, 75(3), 741-747 (2010-01-02)
A number of N-substituted azacalix[4]pyrimidines were synthesized by two methods. While straightforward condensation reaction between 4,6-dichloropyrimidine and 4,6-bis(alkylamino)pyrimidines gave identically N-substituted azacalix[4]pyrimidines in low yields, a general and moderate-to-high yielding 1 + 3 macrocyclic fragment coupling reaction afforded azacalix[4]pyrimidines that
Tetrahedron, 62, 10055-10055 (2006)
Richard T Wheelhouse et al.
Journal of medicinal chemistry, 49(17), 5187-5198 (2006-08-18)
Biarylpyrimidines are characterized as selective ligands for higher-order nucleic acid structures. A concise and efficient synthesis has been devised incorporating Suzuki biaryl cross-coupling of dihalopyrimidines. Two ligand series are described based on the parent thioether 4,6-bis[4-[[2-(dimethylamino)ethyl]mercapto]phenyl]pyrimidine (1a) and amide 4,6-bis(4[(2-(dimethylamino)ethyl)carboxamido]phenyl)pyrimidine
Electrochemical reduction of halogenated pyrimidines at mercury cathodes in acetonitrile.
Ji C, et al.
Journal of Electroanalytical Chemistry, 500(1), 3-11 (2001)

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