14462
(−)-α-甜没药醇
≥93% (GC)
别名:
(-)-6-甲基-2-(4-甲基-3-环己烯-1-基)-5-庚烯-2-醇, 左美诺醇
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经验公式（希尔记法）:
C15H26O
化学文摘社编号:
分子量:
222.37
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
208-205-9
MDL number:
Assay:
≥93% (GC)
InChI key
RGZSQWQPBWRIAQ-CABCVRRESA-N
InChI
1S/C15H26O/c1-12(2)6-5-11-15(4,16)14-9-7-13(3)8-10-14/h6-7,14,16H,5,8-11H2,1-4H3/t14-,15+/m1/s1
SMILES string
C\C(C)=C\CC[C@](C)(O)[C@H]1CCC(C)=CC1
assay
≥93% (GC)
optical activity
[α]/D -58±5°, neat
refractive index
n20/D 1.496
functional group
hydroxyl
Quality Level
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General description
(-)-α-红没药醇是膜壳藻 Hymenocrater yazdianus 叶精油的主要成分。
Application
(-)-α-采用红没药醇 (Bisabolol) 对木香挥发油的杀利什曼病活性和细胞毒活性进行了研究。
Biochem/physiol Actions
α-红没药醇对原代急性白血病细胞有活性，包括 BCR-ABL (+) 急性淋巴细胞白血病 。它是大鼠气管平滑肌电压依赖性钙通道的抑制剂 。还可抑制人和大鼠胶质瘤细胞生长和存活 。是一种潜在的抗利什曼病的新型治疗药物 。
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
存储类别
10 - Combustible liquids
flash_point_f
289.4 °F - closed cup
flash_point_c
143 °C - closed cup
ppe
Eyeshields, Gloves
Shiva Masoudi et al.
Natural product communications, 7(1), 117-120 (2012-03-21)
Water-distilled essential oils from leaves of Hymenocrater yazdianus Rech.f., flowers of Stachys obtusicrena Boiss., and stems and flowers of Nepeta asterotricha Rech.f., which are endemic to Iran, were analyzed by GC and GC/MS. Fifty-five components of the leaf oil of
Aracélio Viana Colares et al.
Evidence-based complementary and alternative medicine : eCAM, 2013, 727042-727042 (2013-08-13)
The search for new immunopharmacological chemical agents to treat various diseases caused by bacteria, fungi, and protozoa, such as leishmaniasis, for example, has led to the exploration of potential products from plant species and their main active ingredients. Antimonial drugs
Orazio Taglialatela-Scafati et al.
Journal of natural products, 75(3), 453-458 (2012-02-09)
Apart from a large amount (ca. 2.0%) of α-bisabolol β-D-fucopyranoside (2a), the aerial parts of the Mediterranean weed Carthamus glaucus afforded an unusual triglyceride (E-2-crotonyl-1,3-distearolylglycerol, 7), two lipophilic flavonoids (6a,b), and a series of bisabolane fucopyranosides variously acylated on the
Chiaki Nakano et al.
Chembiochem : a European journal of chemical biology, 12(15), 2271-2275 (2012-10-30)
Now found in bacteria: An increasing number of genome sequences indicate that bacteria possess a variety of terpenoid cyclase genes. The characterization of two sesquiterpene cyclase (SC) genes found in the draft genome sequence of Streptomyces citricolor is described here.
Nayrton Flávio Moura Rocha et al.
Naunyn-Schmiedeberg's archives of pharmacology, 384(6), 525-533 (2011-08-27)
(-)-α-Bisabolol is an unsaturated, optically active sesquiterpene alcohol obtained by the direct distillation of essential oil from plants such as Vanillosmopsis erythropappa and Matricaria chamomilla. (-)-α-Bisabolol has generated considerable economic interest, as it possesses a delicate floral odour and has
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