143847
2,4-二氯嘧啶
98%
别名:
2,4-二氯嘧啶, 2,6-二氯嘧啶
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C4H2Cl2N2
化学文摘社编号:
分子量:
148.98
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
223-508-6
Beilstein/REAXYS Number:
110911
MDL number:
产品名称
2,4-二氯嘧啶, 98%
InChI key
BTTNYQZNBZNDOR-UHFFFAOYSA-N
InChI
1S/C4H2Cl2N2/c5-3-1-2-7-4(6)8-3/h1-2H
SMILES string
Clc1ccnc(Cl)n1
assay
98%
form
solid
bp
101 °C/23 mmHg (lit.)
mp
57-61 °C (lit.)
functional group
chloro
Quality Level
正在寻找类似产品? 访问 产品对比指南
Application
2,4-二氯嘧啶被用于合成具有重要药用价值的4-芳基-5-嘧啶基咪唑。
General description
2,4-二氯嘧啶是一种人类皮肤致敏剂。它经过有效的一锅法区域选择性双Suzuki偶联反应，产生二芳基化嘧啶。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Samantha C Anderson et al.
Synthesis, 2010(16), 2721-2724 (2010-08-01)
An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed, which enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solvent proved critical to the success of this reaction sequence, with alcoholic solvent mixtures affording
Xiaohu Deng et al.
Organic letters, 8(2), 269-272 (2006-01-18)
[reaction: see text] Starting from 2,4-dichloropyrimidine, a concise synthetic route to medicinally important 4-aryl-5-pyrimidinylimidazoles is described. Sequential substitution of the 4- and 2-chloro groups using a regioselective Sonogashira coupling, followed by nucleophilic substitution, led to pyrimidinylalkyne derivatives, which were then
Bodo Scheiper et al.
The Journal of organic chemistry, 69(11), 3943-3949 (2004-05-22)
Cheap, readily available, air stable, nontoxic, and environmentally benign iron salts such as Fe(acac)(3) are excellent precatalysts for the cross-coupling of Grignard reagents with alkenyl triflates and acid chlorides. Moreover, it is shown that dichloroarene and -heteroarene derivatives as the
Charles Q Huang et al.
Bioorganic & medicinal chemistry letters, 14(9), 2083-2086 (2004-04-15)
A series of 2-dialkylamino-4-phenylpyrimidines (7) was designed and synthesized as CRF(1) antagonists. SAR studies of this series resulted in the discovery of potent and selective antagonists 7b and 7n bearing a 4-(2,4,6-trisubstituted-phenyl) ring and a bulky 2-(N-bis(cyclopropane)methyl-N-propyl)amino group.
Mahbub Alam et al.
Bioorganic & medicinal chemistry letters, 17(12), 3463-3467 (2007-04-27)
The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持