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经验公式(希尔记法):
C10H8N2S2
化学文摘社编号:
分子量:
220.31
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
218-343-1
Beilstein/REAXYS Number:
154629
MDL number:
产品名称
Aldrithiol™-2, 98%
InChI key
HAXFWIACAGNFHA-UHFFFAOYSA-N
InChI
1S/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H
SMILES string
S(Sc1ccccn1)c2ccccn2
assay
98%
form
solid
mp
56-58 °C (lit.)
solubility
methanol: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
functional group
disulfide
storage temp.
2-8°C
Quality Level
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Application
硫醇试剂。在高效液相色谱分离中,与 PPh3 一起作为缩合试剂,用于羧酸对映异构体的酰胺化作用。
醛糖醇™-2可用于合成腺苷-5′-磷酰咪唑内酯。它与PPh3一起使用,可作为HPLC分离羧酸对映体酰胺化反应的缩合剂。
General description
醛糖醇™-2是一种核衣壳锌指靶标化合物,可以消除人免疫缺陷病毒1型 病毒的感染性。它是一种硫醇试剂。
Legal Information
Aldrithiol is a trademark of Sigma-Aldrich Co. LLC
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
J L Rossio et al.
Journal of virology, 72(10), 7992-8001 (1998-09-12)
Whole inactivated viral particles have been successfully used as vaccines for some viruses, but procedures historically used for inactivation can denature virion proteins. Results have been inconsistent, with enhancement of disease rather than protection seen in some notable instances following
Journal of Chromatography A, 662, 87-87 (1994)
Analytical Sciences, 10, 17-17 (1994)
Tetrahedron Letters, 35, 1267-1267 (1994)
T L Dutka et al.
The Journal of physiology, 589(Pt 9), 2181-2196 (2010-12-01)
S-Nitrosoglutathione (GSNO) is generated in muscle and may S-glutathionylate and/or S-nitrosylate various proteins involved in excitation–contraction (EC) coupling, such as Na+-K+-ATPases, voltage-sensors (VSs) and Ca2+ release channels (ryanodine receptors,RyRs), possibly changing their properties. Using mechanically skinned fibres from rat extensor
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