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Merck
CN
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文件

142859

Sigma-Aldrich

二氟乙酸

98%

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别名:
1,1-Difluoroacetic acid, 2,2-Difluoroacetic acid
线性分子式:
F2CHCO2H
CAS号:
381-73-7
分子量:
96.03
Beilstein:
1098588
EC 号:
206-839-0
MDL编号:
MFCD00004220
UNSPSC代码:
12352106
PubChem化学物质编号:
24848539
NACRES:
NA.22

质量水平

200

检测方案

98%

形式

liquid

折射率

n20/D 1.344 (lit.)

bp

132-134 °C (lit.)

mp

−1 °C (lit.)

密度

1.526 g/mL at 25 °C (lit.)

SMILES字符串

OC(=O)C(F)F

InChI

1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)

InChI key

PBWZKZYHONABLN-UHFFFAOYSA-N

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相关类别

一般描述

二氟乙酸是一种单羧酸，也是一种有机氟化合物。二氟乙酸是一种易于操作的试剂，用于制备二氟甲基取代基。二氟乙酸可用作直接对杂环化合物进行C−H二氟甲基化的二氟甲基化试剂。

应用

用于在三苯基膦的介导下，由邻位取代苯胺制备 2-二氟化甲基苯并咪唑、-噁唑和-噻唑。

象形图

CorrosionExclamation mark
GHS05,GHS07

警示用语：

Danger

危险声明

H314,H332,H412

危险分类

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

WGK

WGK 3

闪点(°F)

closed cup

闪点(°C)

closed cup

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Gaëlle Blond et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 8(13), 2917-2922 (2002-12-20)
Ethers of trifluoroacetaldehyde hemiaminals can undergo dehydrofluorination under basic conditions to provide ethers of difluoroketene hemiaminals. The latter behave as equivalents of difluoroacetamide or difluoroacetate anions towards various electrophiles, yielding a range of difluoromethylcarbonyl products.
Hoffman B M Lantum et al.
Toxicological sciences : an official journal of the Society of Toxicology, 70(2), 261-268 (2002-11-21)
Dichloroacetic acid (DCA), chlorofluoroacetic acid (CFA), and difluoroacetic acid (DFA) are inhibitors of pyruvate dehydrogenase kinase. DCA is used for the clinical management of congenital lactic acidosis. Glutathione transferase zeta (GSTZ1-1) catalyzes the biotransformation of DCA and CFA, and DCA
J M Dalstein et al.
Comptes rendus des seances de la Societe de biologie et de ses filiales, 174(5), 821-825 (1980-01-01)
In the anesthetized rat, the intraperitoneal injection of 40 mg/kg sodium difluoroacetate (DFA), an activator of the pyruvate dehydrogenase, counteracted the hyperlactatemia induced by a high dose of phenformin (40 mg/kg) injected concomitantly. In the normal conscious dog, the administration
J N Commandeur et al.
Biochemical pharmacology, 37(23), 4495-4504 (1988-12-01)
The biotransformation and the hepato- and nephrotoxicity of the mercapturic acids (N-acetyl-1-cysteine S-conjugates) of three structurally related 2,2-difluoroethylenes were investigated in vivo in the rat. All mercapturic acids appeared to cause nephrotoxicity, without any measureable effect on the liver. The
Difluoroacetic acid as a new reagent for direct C- H difluoromethylation of heteroaromatic compounds
Tung TT, et al.
Chemistry?A European Journal , 23(72), 18125-18128 (2017)
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