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质量水平
方案
96%
表单
powder
mp
181-183 °C (lit.)
溶解性
alcohol: very slightly soluble
diethyl ether: very slightly soluble
hydrochloric acid: freely soluble (hot)
官能团
nitro
SMILES字符串
Oc1ccc([N+]([O-])=O)c2cccnc12
InChI
1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H
InChI key
RJIWZDNTCBHXAL-UHFFFAOYSA-N
应用
8-羟基-5-硝基喹啉用于合成新型CO2可溶性8-羟基喹啉螯合剂。
生化/生理作用
8-羟基-5-硝基喹啉是一种有效的抗菌剂和抗癌剂。这是治疗革兰氏阴性杆菌所致各种尿路感染的有效药物。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Serena Veschi et al.
Journal of experimental & clinical cancer research : CR, 37(1), 236-236 (2018-09-23)
Pancreatic cancer (PC) is the fourth most common cause of cancer death. Combination therapies with classical chemotherapeutic agents improved treatment of advanced PC at the cost of a relevant toxicity, but the 5-year survival rate remains below 5%. Consequently, new
Highly CO2-soluble 5-Amido-8-hydroxyquinoline Chelating Agents for Extraction of Metals in Sc-CO2.
Chang F, et al.
Bull. Korean Chem. Soc., 29(7), 1327-1327 (2008)
B Murugasu-Oei et al.
International journal of antimicrobial agents, 18(6), 579-582 (2001-12-12)
The chelating antibiotic nitroxoline (5-nitro-8-hydroxyquinoline) showed a bacteriostatic effect at a concentration of 10 microM for Mycobacterium bovis BCG. At higher concentrations the compound showed moderate cidal activity against growing bacilli. In contrast, its non-nitrated derivative oxine (8-hydroxyquinoline, MIC=2 microM)
Serena Veschi et al.
Journal of enzyme inhibition and medicinal chemistry, 35(1), 1331-1344 (2020-06-27)
Pancreatic cancer (PC) is one of the deadliest carcinomas and in most cases, which are diagnosed with locally advanced or metastatic disease, current therapeutic options are highly unsatisfactory. Based on the anti-proliferative effects shown by nitroxoline, an old urinary antibacterial
Shridhar Bhat et al.
Organic & biomolecular chemistry, 10(15), 2979-2992 (2012-03-07)
Two substituted oxines, nitroxoline (5) and 5-chloroquinolin-8-yl phenylcarbamate (22), were identified as hits in a high-throughput screen aimed at finding new anti-angiogenic agents. In a previous study, we have elucidated the molecular mechanism of antiproliferative activity of nitroxoline in endothelial
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