140112
4-硝基苄氯
99%
别名:
α-氯-4-硝基甲苯
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关于此项目
线性分子式:
O2NC6H4CH2Cl
化学文摘社编号:
分子量:
171.58
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-822-7
Beilstein/REAXYS Number:
387187
MDL number:
Assay:
99%
Form:
solid
mp
70-73 °C (lit.)
solubility
chloroform: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow
functional group
chloro, nitro
InChI key
KGCNHWXDPDPSBV-UHFFFAOYSA-N
InChI
1S/C7H6ClNO2/c8-5-6-1-3-7(4-2-6)9(10)11/h1-4H,5H2
SMILES string
[O-][N+](=O)c1ccc(CCl)cc1
assay
99%
form
solid
Quality Level
General description
用对硝基苯氯作为谷胱甘肽 S-转移酶 (GST) 的底物测定中国人胎肝中的 GST 。它被 NADPH 还原生成 4-硝基甲苯 。
Application
用对硝基氯化苄不对称合成了 N，N′- 双 （取代）4,13-二氮杂-18-冠-6-醚衍生物。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
危险化学品
此项目有
P Jemth et al.
The Journal of biological chemistry, 275(12), 8618-8624 (2000-03-18)
Ser(11) in rat glutathione transferase T2-2 is important for stabilization of the reactive enzyme-bound glutathione thiolate in the reaction with 1-menaphthyl sulfate. The S11A mutation increased the pK(a) value for the pH dependence of the rate constant for pre-steady-state product
Tetrahedron Letters, 34, 95-95 (1993)
S B Lei et al.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 11(5), 389-391 (1990-09-01)
Subcellular fractions were isolated from Chinese fetal liver at 4-8 months of age for the determination of glutathione S-transferase (GST). Using 1-chloro-2,4-dinitrobenzene (CDNB) as substrate, GST activity was found to be 66 +/- 34 nmol/(min.mg protein), mainly in the cytosol.
S V Singh et al.
Experimental eye research, 41(3), 405-413 (1985-09-01)
When rats were orally administered a daily dose of 300 mg kg-1 body weight of 3,5-di-t-butyl-4-hydroxytoluene (BHT) for 4 days, about 90% increase over basal level in total glutathione (GSH) S-transferase activity towards 1-chloro-2,4-dinitrobenzene (CDNB) was observed in ocular lens.
S N Moreno et al.
The Journal of biological chemistry, 261(17), 7811-7815 (1986-06-15)
The o-, m-, and p-nitrobenzyl chlorides are reduced aerobically and anaerobically by NADPH and rat hepatic microsomes. Under aerobic conditions, these nitro anion radicals reduce oxygen to superoxide as demonstrated by oxygen consumption and spin trapping of superoxide with 5,5-dimethyl-1-pyrroline
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