139181
溴二氯甲烷
≥97%
别名:
二氯溴甲烷
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关于此项目
线性分子式:
BrCHCl2
化学文摘社编号:
分子量:
163.83
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-856-7
Beilstein/REAXYS Number:
1697005
MDL number:
Assay:
≥97%
Form:
liquid
InChI key
FMWLUWPQPKEARP-UHFFFAOYSA-N
InChI
1S/CHBrCl2/c2-1(3)4/h1H
SMILES string
ClC(Cl)Br
assay
≥97%
form
liquid
contains
potassium carbonate as stabilizer
refractive index
n20/D 1.497 (lit.)
bp
87 °C (lit.)
mp
−55 °C (lit.)
solubility
water: insoluble
density
1.98 g/mL at 25 °C (lit.)
functional group
bromo, chloro
Quality Level
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Application
溴二氯甲烷用于研究“氯二溴甲烷、溴二氯甲烷和溴仿在小鼠体内”的遗传毒性。
Biochem/physiol Actions
溴二氯甲烷 (BDCM) 诱导人肝脏脂肪性肝炎损伤。BDCM在雄性F344大鼠中通过肾小管细胞增殖诱导不同组织的细胞增殖和肾损害。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
K J Stocker et al.
Mutagenesis, 12(3), 169-173 (1997-05-01)
Chlorination of drinking water results in the formation of chlorodibromomethane, bromodichloromethane and bromoform. These trihalomethanes have all shown evidence of genotoxicity in bacterial and mammalian cell systems in vitro and some evidence of carcinogenicity in rodents. Chlorodibromomethane and bromodichloromethane have
Ratanesh Kumar Seth et al.
Toxicology and applied pharmacology, 274(1), 42-54 (2013-11-12)
Environmental toxins induce a novel CYP2E1/leptin signaling axis in liver. This in turn activates a poorly characterized innate immune response that contributes to nonalcoholic steatohepatitis (NASH) progression. To identify the relevant subsets of T-lymphocytes in CYP2E1-dependent, environment-linked NASH, we utilized
Richard J Summerhayes et al.
Epidemiology (Cambridge, Mass.), 23(1), 15-22 (2011-12-14)
Trihalomethanes in drinking water have been associated with higher occurrence of small-for-gestational-age (SGA) births, although results have been inconsistent. We geocoded residential address for mother of live, singleton, term births to 33 water distribution systems in a large metropolitan area
Regina Grazuleviciene et al.
Occupational and environmental medicine, 70(4), 274-282 (2013-02-14)
Congenital anomalies have been inconsistently associated with maternal crude estimated exposure to drinking water trihalomethane (THM). We investigated the relationship between individual THM uptake during the first trimester of pregnancy and congenital anomalies. We estimated maternal THM uptake for 3074
Suvarthi Das et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(12), G950-G963 (2013-10-26)
Recent studies indicate that metabolic oxidative stress, autophagy, and inflammation are hallmarks of nonalcoholic steatohepatitis (NASH) progression. However, the molecular mechanisms that link these important events in NASH remain unclear. In this study, we investigated the mechanistic role of purinergic
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