138630
1-氯-2,4-二硝基苯
97%
别名:
2,4-二硝基氯苯, CDNB, DNCB
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关于此项目
线性分子式:
ClC6H3(NO2)2
化学文摘社编号:
分子量:
202.55
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-551-4
Beilstein/REAXYS Number:
613161
MDL number:
产品名称
1-氯-2,4-二硝基苯, 97%
InChI key
VYZAHLCBVHPDDF-UHFFFAOYSA-N
InChI
1S/C6H3ClN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
SMILES string
[O-][N+](=O)c1ccc(Cl)c(c1)[N+]([O-])=O
assay
97%
form
solid
expl. lim.
22 %
bp
315 °C (lit.)
mp
48-50 °C (lit.)
solubility
alcohol: soluble (hot)
alcohol: very slightly soluble (cold)
benzene: soluble
carbon disulfide: soluble
diethyl ether: soluble
water: insoluble
functional group
chloro
nitro
Quality Level
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Application
1-氯代-2,4-二硝基苯用于逆相HPLC检测人体组织中单个谷胱甘肽S转移酶亚基相对含量。它可作为接触敏化剂，研究抗菌肽链hBD-2,-3和-4以及LL-37诱导的人角质细胞 IL-18蛋白质释放。
Biochem/physiol Actions
2,4-二硝基氯代笨诱发BALB/c小鼠模型特应性皮炎。
Preparation Note
当作为谷胱甘肽S转移酶底物时，将该产品溶于乙醇，然后加入缓冲溶液，形成终浓度为1mM的磷酸盐缓冲液 (8 mL 0.2M KH2PO4和28ml 0.1M Na2HPO4每100ml溶液，调节到pH6.5）4%(v/v)乙醇。
signalword
Danger
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 2
flash_point_f
381.2 °F - closed cup
flash_point_c
194 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
危险化学品
此项目有
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Journal of hazardous materials, 370, 42-53 (2018-09-15)
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J D Rowe et al.
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Journal of immunology (Baltimore, Md. : 1950), 175(3), 1776-1784 (2005-07-22)
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R Li et al.
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