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质量水平
检测方案
97%
形式
solid
expl. lim.
22 %
bp
315 °C (lit.)
mp
48-50 °C (lit.)
溶解性
alcohol: soluble (hot)
alcohol: very slightly soluble (cold)
benzene: soluble
carbon disulfide: soluble
diethyl ether: soluble
water: insoluble
SMILES字符串
[O-][N+](=O)c1ccc(Cl)c(c1)[N+]([O-])=O
InChI
1S/C6H3ClN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
InChI key
VYZAHLCBVHPDDF-UHFFFAOYSA-N
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应用
1-氯代-2,4-二硝基苯用于逆相HPLC检测人体组织中单个谷胱甘肽S转移酶亚基相对含量。它可作为接触敏化剂，研究抗菌肽链hBD-2,-3和-4以及LL-37诱导的人角质细胞 IL-18蛋白质释放。
生化/生理作用
2,4-二硝基氯代笨诱发BALB/c小鼠模型特应性皮炎。
制备说明
当作为谷胱甘肽S转移酶底物时，将该产品溶于乙醇，然后加入缓冲溶液，形成终浓度为1mM的磷酸盐缓冲液 (8 mL 0.2M KH2PO4和28ml 0.1M Na2HPO4每100ml溶液，调节到pH6.5）4%(v/v)乙醇。
警示用语：
Danger
危险分类
Acute Tox. 2 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1
WGK
WGK 2
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
危险化学品
François Niyonsaba et al.
Journal of immunology (Baltimore, Md. : 1950), 175(3), 1776-1784 (2005-07-22)
In addition to its physical barrier against invading microorganisms, the skin produces antimicrobial peptides, human beta-defensins (hBDs) and cathelicidin LL-37, that participate in the innate host defense. Because IL-18 is produced by keratinocytes and involved in skin diseases in which
J D Rowe et al.
The Biochemical journal, 325 ( Pt 2), 481-486 (1997-07-15)
Uncertainties about the composition and identities of glutathione S-transferases (GSTs) in human tissue have impeded studies on their biological functions. A rigorous protocol has therefore been developed to characterize the human proteins. Cytosolic GST subunits were resolved by reverse-phase HPLC
Antony Anet et al.
Journal of hazardous materials, 370, 42-53 (2018-09-15)
This study investigates Bisphenol A (BPA) induced oxidative stress that mediates the genotoxicity in in vivo model Drosophila melanogaster. The calculated LC50 for BPA was 12.35 μg/mL. The strains of D. melanogaster were reared in 0.1, 1.0, 2.5 and 5.0 μg/mL BPA
R Li et al.
Allergy, 67(10), 1250-1258 (2012-08-23)
We previously reported that prior nasal administration of highly attenuated Bordetella pertussis BPZE1 provides effective and sustained protection against lethal challenge with influenza A viruses. The protective effect was mediated by suppressing the production of major pro-inflammatory mediators. To further
L S Tran et al.
The Journal of investigative dermatology, 134(9), 2438-2446 (2014-04-16)
We have shown that the expression of human papillomavirus type 16 E7 (HPV16.E7) protein within epithelial cells results in local immune suppression and a weak and ineffective immune response to E7 similar to that occuring in HPV-associated premalignancy and cancers.
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